Formulation of Tempuyung (Sonchus arvensis L.) Nano Herbal in Self Nano-Emulsion Drug Delivery System (SNEDDS) Preperation
Article Sidebar
Main Article Content
Abstract
Tempuyung (Sonchus arvensis L.) is a plant native to Indonesia with a diuretic and antioxidant effect. To obtain the optimal therapeutic effect need innovation to make it the nano herbs preparations. This research aims to preparation and characterization of nano herbal tempuyung in the form of Nano Self-emulsifying Drug Delivery System (SNEDDS). The active substance of tempuyung was extracted with ethanol and the solvent evaporated to obtain a viscous extract. Extracts were standardized following the Indonesian Pharmacopeia Herbal. Next, the SNEDDS of tempuyung were made using Capryol-90 as oils, tween 20 as surfactants and PEG 400 as co-surfactant. SNEDDS was characterized include particle size and zeta potential. The viscous extract obtained from extraction was 77.52 g. This result has been eligible if compared with Indonesian Pharmacopoeia Herbal that mentions the acquisition of thick leaf extract tempuyung yield is not less than 7.5%. Tempuyung formulation in dosage forms SNEDDS obtained a clear nanoemulsion with a particle size of 16.2 ± 1.06 nm and zeta potential value of -37.48 ± 0.74 mV. It can be concluded that the tempuyung extract can produce a nano herbs in SNEDDS preparation.
Article Details
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Sukadana IM, Santi SR. (2011). Senyawa Antibakteri Bis (2-Etilheksil) Ester dan Triterpenoid dalam Ekstrak n-Heksan Daun Tempuyung (Sonchus arvensis L.). Maj Obat Tradis,16(1),1-6.
Syukri Y, Nugroho AE, Martien R, Lukitaningsih E. (2015). Validasi Penetapan Kadar Isolat Andrografolid dari Tanaman Sambiloto (Andrographis paniculata Nees) Menggunakan HPLC. J Sains Farm Klin, 2(1), 8-14.
Sprunk A, Strachan CJ, Graf A. (2012). Rational formulation development and in vitro assessment of SMEDDS for oral delivery of poorly water soluble drugs. Eur J Pharm Sci, 46(5), 508-515.
Syukri Y, Fernenda L, Utami FR, Qiftayati I, Kusuma AP, Istikaharah R. (2015). Preperation And Characterization Of Î’-Cyclodextrin Inclusion Complexes Oral Tablets Containing Poorly Water Soluble Glimipiride Using Freeze Drying Method. Indones J Pharm, 26(2), 71.
Krishnaiah YS. (2010). Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs. J Bioequivalence Bioavailab [Internet]. [cited 2016 Jun 14];2(2). Available from: https://www.omicsonline.org/pharmaceutical-technologies-for-enhancing-oral-bioavailability-of-poorly-soluble-drugs-jbb.1000027.php?aid=605
Müllertz A, Ogbonna A, Ren S, Rades T. (2010). New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs: Lipid and surfactant drug delivery systems. J
Balata G, Eassa E, Shamrool H, Zidan S, Abdo Rehab M. (2016). Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol. Drug Des Devel Ther, 117
Dash RN, Mohammed H, Humaira T, Ramesh D. (2015). Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution. Saudi Pharm J, 23(5), 528-540.
Fahmy UA, Ahmed OAA, Hosny KM. (2015). Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability. AAPS PharmSciTech, 16(1):53-58.
Kamble RN, Mehta PP, Kumar A. (2015). Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro and In Vivo Evaluation. AAPS PharmSciTech [Internet]. [cited 2016 Jun 14]; Available from: https://link.springer.com/10.1208/s12249-015-0446-2
Kamble M, Borwandkar VG, Mane SS, Omkar R. (2012). Formulation and evaluation of lipid based nanoemulsion of glimepiride using self-emulsifying technology. Indo Am J Pharm Res, 2, 1011-1025.
Anonim. (2008). Farmakope Herbal Indonesia. Jakarta: Departemen Kesehatan RI.
Sriamornsak P, Limmatvapirat S, Piriyaprasarth S, Mansukmanee P, Huang Z. (2015). A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution. Asian J Pharm Sci, 10(2), 121-127.