Pemanfaatan Iradiasi Gelombang Mikro pada Sintesis Metil orto-metoksisinamat

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Published: Aug 6, 2021
DOI: https://doi.org/10.25077/jsfk.8.2.157-163.2021
Keywords:
Asam orto-hidroksisinamat, Metil orto-Metoksisinamat, Microwave, reaksi metilasi

Main Article Content

Istna Nur’ainul Yaqin
Fakultas Farmasi Universitas Airlangga
Juni Ekowati
Fakultas Farmasi Universitas Airlangga
Kholis Amalia Nofianti
Fakultas Farmasi Universitas Airlangga
Suzana Suzana
Fakultas farmasi Universitas Airlangga

Abstract

Tujuan penelitian ini adalah mensintesis senyawa metil orto-metoksisinamat (MOMS) yang terbukti berdasarkan uji in silico dapat digunakan mengobati penyakit kardiovaskular, yaitu sebagai antiplatelet. Sintesis MOMS dilakukan dari material awal asam orto-hidroksisinamat (AOHS) dengan metode iradiasi gelombang mikro dan membandingkan profil KLT selama proses reaksi sintesis pada tiga daya iradiasi gelombang mikro tersebut (120, 280 dan 400Watt). Reaksi yang digunakan adalah reaksi metilasi pada gugus OH asam karboksilat dan gugus fenolik dari senyawa AOHS dengan dimetil sulfat sebagai agen pemetilasi. Kondisi reaksinya diatur dalam suasana basa K2CO3 menggunakan pelarut aseton. Pengambilan sampel pada proses reaksi sintesis dilakukan setiap 30 detik pada masing-masing daya microwave dan dievaluasi noda yang terbentuk pada plat kromatografi lapisan tipis (KLT), dan dilanjutkan sampai reaksi sempurna. Hasil penelitian menunjukkan bahwa kesempurnaan reaksi semakin cepat dengan bertambahnya daya microwave. Prosentase hasil yang diperoleh 72%. Berdasarkan analisis senyawa menggunakan spektrofotometer FT-IR, spektrometer 1H-NMR dan 13C-NMR, disimpulkan bahwa reaksi sintesis senyawa MOMS dapat dilakukan dengan memanfaatkan iradiasi gelombang mikro, hal ini disebabkan adanya gugus polar pada AOHS yang dapat menyerap iradiasi gelombang mikro. Semakin tinggi daya yang digunakan pada reaksi metilasi AOHS, maka semakin cepat waktu yang dibutuhkan untuk kesempurnaan reaksi

Article Details

How to Cite
Yaqin, I. N., Ekowati, J., Nofianti, K. A., & Suzana, S. (2021). Pemanfaatan Iradiasi Gelombang Mikro pada Sintesis Metil orto-metoksisinamat. Jurnal Sains Farmasi & Klinis, 8(2), 157–163. https://doi.org/10.25077/jsfk.8.2.157-163.2021
Issue
Vol. 8 No. 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Section
Research Articles
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Author Biographies

Istna Nur’ainul Yaqin, Fakultas Farmasi Universitas Airlangga

Departemen Ilmu Kefarmasian, Mahasiswa

Juni Ekowati, Fakultas Farmasi Universitas Airlangga

Departemen Ilmu Kefarmasian, Lektor Kepala

Kholis Amalia Nofianti, Fakultas Farmasi Universitas Airlangga

Departemen Ilmu Kefarmasian, Lektor

Suzana Suzana, Fakultas farmasi Universitas Airlangga

Departemen Ilmu Kefarmasian, Lektor Kepala

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