Study of the solid dispersion systems Klaritromisin-Eudragit L100
Article Sidebar
Main Article Content
Abstract
Solid dispersion made with the weight ratio (b/b) using the dissolving method. DTA analysis of the solid dispersion obtained in Eudragit L 100 affects the position and sharpness of the peak. X-ray diffraction analysis showed that of clarithromycin - Eudragit L 100 is in amorphous form and did not produce a new crystalline phase. SEM analysis showed that crystalline of Eudragit L 100 is smaller (amorphous) and stick to the surface of the clarithromycin crystal. IR spectrophotometer analysis showed that there is no chemical interaction between clarithromycin and Eudragit L 100. Clarithromycin assay was done by HPLC method, using mobile phase methanol and 0.067 M KH2PO4 (13:7) plus fospat acid pH 4.0. The dissolution profile by the time of 60 minutes are clarithromycin 45.73%, CF (1:1) 49.86%, DP (1:1) 51.53%, DP (2:1) 55.87% and DP (1:2) 58.97% respectively. Solid dispersion 1:2 (w/w) have an increased dissolution rate compared to clarithromycin.
Article Details
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Shargel, L., B. C. Yu and Adrew. (2005). Biofarmasetika Farmakokinetika Serapan (Edisi 2). Penerjemah: Fasich. Surabaya: Unair Press.
Ansel, Howard C. (1989). Pengantar Bentuk Sediaan Farmasi (F.Ibrahim, Trans. IV ed.). Jakarta: UI Press.
Chiou, W. L., & Riegelman, S. (1971). Pharmaceutical Applications of Solid Dispersion System. J. of Pharm. Sci., 60, (9), 1281-1302.
Ganiswara,S. (2007). Farmakologi dan Terapi. Edisi kelima. Bagian Farmakologi FKUI. Jakarta. Universitas Indonesia Press. Hal. 720-721
Goodman,L.S., and A.,Gilman.,(1990).,The Pharmacologic Basic Of Therapetic Eighth Edition.,Mc Millan Publication Co, New York.
Martindale, (1982), The Extra Pharmacopeia ed 28th, The Pharmaceutical Press, London.
Lennernas,H.,Abrahamsson, B.,(2005). The use of biopharmaceutic classification if drugs in drug discovery and development: current status and future extension.J.Pharm.Pharmacol.57,273-85
Mohammadi, G., Hemati, V., Nikbakht, M.-R., ShahlaMirzaee, Fattahi, A., Ghanbari, K., & Adibkia, K. (2014). In vitro and in vivoevaluation of clarithromycin–urea solid dispersions prepared by solvent evaporation, electrospraying and freeze drying methods. Powder Technol, 257, 168-174.
Pereira Junia,M., Ariza Raquel Mejia, ilevbare A Grace, E.Mc Gettigan Heather (2013).“Interplay of Degradation, Dissolution and Stabilization of Claritromycin and its Amorphous Solid Dispersionâ€. Molecular pharmaceutics.,10,4640-4653.
Departemen Kesehatan Republik Indonesia (2010), Suplemen II Farmakope Indonesia ( Edisi IV), Jakarta., Departemen Kesehatan Republik Indonesia.
Rowe, R. C, Paul J.S, Sian C.O (2006). Handbook of Pharmaceutical Excipient, (5 th Ed). London: The Pharmaceutical Press
Kritika Thakur., Nagpal Meenu.,Aggarval Geeta., Kaur Rupinder., Kumar Jain Upendra.,(2014). Development and Evaluation of Solid Dispersion Using Binary and Ternary Complexes., Departemen of Pharmaceutics., India., 1793-1812.
Departemen Kesehatan Republik Indonesia ( 2011) , Suplemen III Farmakope Indonesia ( Edisi IV), Jakarta., Departemen Kesehatan Republik Indonesia.
Fried, Joel R.(1995). Polymer science and technology. New Jersey: Prentice Hall PTR