Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE)

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Published: May 23, 2020
DOI: https://doi.org/10.25077/jsfk.7.1.76-82.2020
Keywords:
antihipertensi, senyawa bioaktif peptida laut, inhibitor Angiotensin-I Converting Enzyme (ACE), pola penghambatan, penambatan molekuler berbasis protein-peptida.

Main Article Content

Taufik Muhammad Fakih
Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Bandung
Mentari Luthfika Dewi
Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Bandung

Abstract

Senyawa bioaktif peptida laut saat ini menjadi fokus penelitian karena memiliki sifat yang unik. Salah satu peran biologis penting dari senyawa peptida tersebut adalah sebagai agen antihipertensi terhadap aktivitas Angiotensin-I Converting Enzyme (ACE). Terdapat beberapa senyawa peptida yang telah terbukti mampu menghambat reseptor ACE, seperti senyawa peptida yang dihasilkan oleh teripang (Acaudina molpadioides), kerang biru (Mytilus edulis), dan ikan tuna (Thunnini). Dalam penelitian ini dilakukan identifikasi dan evaluasi terhadap interaksi yang terjadi antara senyawa peptida dengan reseptor ACE menggunakan motode penambatan molekuler berbasis protein-peptida. Sequencing senyawa peptida dimodelkan terlebih dahulu menggunakan server PEP-FOLD. Konformasi terbaik dipilih untuk dilakukan studi interaksi terhadap makromolekul reseptor ACE menggunakan software PatchDock. Interaksi yang terjadi diamati lebih lanjut menggunakan software BIOVIA Discovery Studio 2020. Berdasarkan hasil dari penambatan molekuler berbasis protein-peptida, senyawa peptida kerang biru dan ikan tuna memiliki afinitas yang baik terhadap reseptor ACE, yaitu dengan ACE score masing-masing adalah −391,62 kJ/mol dan −516,56 kJ/mol. Dengan demikian, senyawa bioaktif peptida laut tersebut diprediksi dapat dipilih sebagai kandidat inhibitor reseptor ACE berbasis peptida

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How to Cite
Fakih, T. M., & Dewi, M. L. (2020). Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE). Jurnal Sains Farmasi & Klinis, 7(1), 76–82. https://doi.org/10.25077/jsfk.7.1.76-82.2020
Issue
Vol. 7 No. 1 (2020): J Sains Farm Klin 7(1), April 2020
Section
Research Articles
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