The implementation of diabetes medication adjustment during ramadan fasting and its effect on HbA1c values

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JSFK 7(2) Agustus 2020
PDF (Bahasa Indonesia)
Published: Aug 31, 2020
DOI: https://doi.org/10.25077/jsfk.7.2.126-134.2020
Keywords:
Drug adjustment, IDF-DAR recommendatio, Ramadan fasting, Diabetes Mellitus type-2, HbA1c.

Main Article Content

Rahmi Safyanty
Fakultas Farmasi Universitas Indonesia
Retnosari Andrajati
Universitas Indonesia
Sudibyo Supardi
Litbangkes Kementerian Kesehatan
Ratu Ayu Dewi Sartika
Universitas Indonesia

Abstract

This study aimed to evaluate the effect of diabetes medication adjustment during Ramadan fasting according to the recommendation of International Diabetes Federation-Diabetes and Ramadan International Alliance (IDF-DAR) to HbA1c values in type-2 diabetes mellitus patients. The study was conducted at a hospital in Jakarta, Indonesia with a cross-sectional study design involving 80 ambulatory patients with type-2 DM who fasted during Ramadan in 2016. About 60% of patients used oral antidiabetes drug (OAD), mostly the combination of biguanide + sulfonylurea drugs (27.5%). The adjustments were made in which 56.2% was in accordance with IDF-DAR recommendations. The study showed that the HbA1c values decreased insignificantly (p = 0.082) from 8.75 ± 1.90 to 8.63 ± 1.82 after the adjustment. The appropriate drug adjustment based on IDF-DAR had a significant effect on the HbA1c value of DM patient with p-value 0.030 (p < 0.05).The discrepancy of drug use based on IDF-DAR 3.222 times greater caused uncontrolled HbA1c. The most influential variable to HbA1c value was drug type with p-value 0.006 (p < 0.05). Improper adjustment of Insulin or combination insulin-OAD caused HbA1c value 5 times greater to be uncontrolled than OAD.

Article Details

How to Cite
Safyanty, R., Andrajati, R., Supardi, S., & Dewi Sartika, R. A. (2020). The implementation of diabetes medication adjustment during ramadan fasting and its effect on HbA1c values. Jurnal Sains Farmasi & Klinis, 7(2), 126–134. https://doi.org/10.25077/jsfk.7.2.126-134.2020
Issue
Vol. 7 No. 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Section
Research Articles
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