Formulasi Granul Effervescent Herba Meniran (Phyllanthus niruri L.) dengan Variasi Suspending Agent Xanthan Gum, CMC-Na, dan Kombinasi CMC-Na-Mikrokristalin Selulosa RC- 591
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Abstract
Herba meniran (Phyllanthus niruri L.) merupakan simplisia tanaman obat yang selama ini digunakan masyarakat dalam bentuk air rebusan. Formulasi herba meniran dalam bentuk granul effervescent dengan penambahan suspending agent merupakan salah satu bentuk inovasi minuman fungsional. Jenis suspending agent yang digunakan dalam formula memiliki pengaruh terhadap karakteristik granul. Penelitian ini bertujuan untuk menganalisis pengaruh perbedaan jenis suspending agent xanthan gum (formula 1), CMC-Na (formula 2), dan kombinasi CMC-Na-mikroskristalin selulosa RC-591 (formula 3) dengan konsentrasi 1% terhadap karakteristik fisika dan kimia granul effervescent sebelum dan sesudah direkonstitusi. Formulasi granul effervescent herba meniran dilakukan dengan metode granulasi basah. Komponen asam dan basa digranulasi secara terpisah kemudian kedua komponen dicampur menggunakan tumbling mixer. Hasil penelitian menunjukkan bahwa granul effervescent yang dihasilkan memenuhi persyaratan dengan persentase fines sebesar 1,02-2,02%; kandungan lembap 3,76±0,13%-3,82±0,30%; kecepatan alir 7,85±0,10-10,92±0,04 g/detik; sudut istirahat 31,12±0,75-34,12±0,75°; waktu dispersi 66,95±5,50-70,26±0,03 detik; tinggi buih 3,01±0,12-3,22±0,25 cm; viskositas 222,0-242 cps; pH 6,73±0,10-6,91±0,01. Formula 1 merupakan formula terbaik karena menghasilkan waktu dispersi yang cepat, dispersi yang halus, dan viskositas yang lebih tinggi. Hasil evaluasi organoleptis dan sensori menunjukkan bahwa formula granul effervescent dalam penelitian ini dapat diterima oleh panelis.Â
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