Antiplatelet, anticoagulant, and thrombolytic cctivities of total alkaloid extract of papaya leaves (Carica papaya L.) in Vitro

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JSFK 7(2) Agustus 2020
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Published: Aug 31, 2020
DOI: https://doi.org/10.25077/jsfk.7.2.115-125.2020
Keywords:
Carica papaya, papaya, akaloid, antiplatelet, anticoagulant, thrombolytic.

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Martina Kurnia Rohmah
Program Studi S1 Farmasi STIKES Rumah Sakit Anwar Medika
Djelang Zainuddin Fickri
Program Studi S1 Farmasi STIKES Rumah Sakit Anwar Medika

Abstract

Papaya leaves have a number of alkaloid compounds (carpaine, pseudocarpaine, dehydrocarpaine I, dehydrocarpaine II, and emetine). This study aimed to determine the antiplatelet, anticoagulant, and thrombolytic activities of total alkaloids of papaya leaves in vitro. This study was divided into 5 groups: negative control, positive control, and total alkaloids of papaya leaves (0.5, 1.0, and 2.0 mg/mL) with 5 parameters: % platelet aggregation inhibition, CT, PT, APTT, and % thrombolytic. Based on statistical analysis, there was a significant difference between percentage of aggregation inhibition of total alkaloids and negative controls, but was not different with positive control (clopidogrel). Anticoagulant test showed that total alkaloid of papaya leaves significantly extended CT, PT, and APTT values compared with negative control, but was not significantly different with positive control (heparin). Thrombolytic test showed that total alkaloid of papaya leaves increased trombolitic percentage and significantly different from the negative control, but was not significantly different from positive control (nattokinase).

Article Details

How to Cite
Rohmah, M. K., & Fickri, D. Z. (2020). Antiplatelet, anticoagulant, and thrombolytic cctivities of total alkaloid extract of papaya leaves (Carica papaya L.) in Vitro. Jurnal Sains Farmasi & Klinis, 7(2), 115–125. https://doi.org/10.25077/jsfk.7.2.115-125.2020
Issue
Vol. 7 No. 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Section
Research Articles
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Author Biographies

Martina Kurnia Rohmah, Program Studi S1 Farmasi STIKES Rumah Sakit Anwar Medika

Departemen Farmasi Klinis, Asisten Ahli

Djelang Zainuddin Fickri, Program Studi S1 Farmasi STIKES Rumah Sakit Anwar Medika

Departemen Farmasi Klinis, Asisten Ahli

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