Formulation and evaluation of the phyical characteristics of scrub cream from ethanolic extract of soursop (Annona muricata L.) leaves and determination of its antioxidant activity

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JSFK 7(2) Agustus 2020
PDF (Bahasa Indonesia)
Published: Aug 31, 2020
DOI: https://doi.org/10.25077/jsfk.7.2.135-142.2020
Keywords:
antioxidants, Annona muricata L, soursop leaves, scrub cream, DPPH

Main Article Content

Zainur Rahman Hakim
Fakultas Farmasi Universitas Muhammadiyah Purwokerto
Dewi Meliana
Fakultas Farmasi Universitas Muhammadiyah Purwokerto
Pri Iswati Utami
Fakultas Farmasi Universitas Muhammadiyah Purwokerto

Abstract

The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent with an IC50 value of 14.48 µg/mL. This research aimed to examine physical characteristics and investigate the antioxidant activity of the ethanolic extract of soursop leaves in a scrub cream. Soursop leaves powder was extracted with 70% ethanol and formulated as scrub cream at the concentration of 1.4%, 2.8%, and 4.2%, then evaluated for physical characteristics. The antioxidant activity was evaluated using DPPH (1.1-diphenyl-2 picrylhydrazyl) method. The result showed that the scrub cream at all concentrations tested fulfilled all physical characteristics required for good topical preparations. These included organoleptic, homogeneity, viscosity, pH, spreadability, and adhesion. The IC50 value of the scrub cream at the concentration of 1.4%, 2.8 %, and 4.2% were 30.72, 26.82, and 24.03 µg/mL, respectively. The IC50 values indicated that the scrub creams exhibit radical scavenging activities which categorized as strong activity antioxidants.

Article Details

How to Cite
Hakim, Z. R., Meliana, D., & Utami, P. I. (2020). Formulation and evaluation of the phyical characteristics of scrub cream from ethanolic extract of soursop (Annona muricata L.) leaves and determination of its antioxidant activity. Jurnal Sains Farmasi & Klinis, 7(2), 135–142. https://doi.org/10.25077/jsfk.7.2.135-142.2020
Issue
Vol. 7 No. 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Section
Research Articles
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Author Biography

Zainur Rahman Hakim, Fakultas Farmasi Universitas Muhammadiyah Purwokerto

Departemen Biologi Farmasi

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