Physicochemical characterization of Binary System of Ciprofloxacin HCl - PEG 4000

Main Article Content

Resva Meinisasti
Auzal Halim
Erizal Zaini

Abstract

"Physicochemical Characterization of Binary Systems Ciprofloxacin HCl - PEG 4000" has been reseach. This study aimed to characterize ciprofloxacin HCl formula that was developed to 9, with a comparison between ciprofloxacin - PEG 4000 following formula I (1: 9), formula II (2: 8), formula III (3: 7), formula IV (4: 6), formula V (5: 5), formula VI (6: 4), formula VII (7: 3), formula VIII (8: 2) and formula IX (9: 1). Binary system made by the manufacture of solid dispersion by melting method. The results of the binary System were characterized by analysis Differential Thermal Analysis (DTA), X-ray diffraction, IR spectrophotometry, and Scanning Electron Microscope (SEM). The results of this analysis have results of the binary solid dispersion systems a good formula this VII.

Article Details

How to Cite
Meinisasti, R., Halim, A., & Zaini, E. (2015). Physicochemical characterization of Binary System of Ciprofloxacin HCl - PEG 4000. Jurnal Sains Farmasi & Klinis, 2(1), 30–35. https://doi.org/10.29208/jsfk.2015.2.1.45
Section
Research Articles

References

Ganiswarna. Farmakologi Dan Terapi. (2007). Jakarta: Universitas Indonesia Press;.

Leuner, C., & Dressman, J. (2000). Improving drug solubility for oral delivery using solid dispersions. European journal of Pharmaceutics and Biopharmaceutics, 50(1), 47-60.

Singh S, Baghel RS, Yadav L. (2011). A review on solid dispersion. International Journal of Pharmacy & Life Sciences, 2(9),1078-1095.

Turel, I., Bukovec, P., & Quirós, M. (1997). Crystal structure of ciprofloxacin hexahydrate and its characterization. International journal of pharmaceutics, 152(1), 59-65.

Zaini, E., Halim, A., Soewandhi, S. N., Setyawan, D., Farmasetika, D., Andalas, U., ... & Si, M. (2011). Peningkatan Laju Pelarutan Trimetoprim Melalui Metode Ko-Kristalisasi Dengan Nikotinamida. Jurnal Farmasi Indonesia Vol, 5(4), 205-212.

Ford J. Thermal Analysis — Fundamentals and Applications to Polymer Science, 2nd Edition, Edited by T. Hatakeyama and F.X. Quinn, Wiley, Chichester, 1999, viii+180 Pages.

Serajuddin, A. (1999). Solid dispersion of poorly waterâ€soluble drugs: early promises, subsequent problems, and recent breakthroughs. Journal of Pharmaceutical Sciences, 88(10), 1058-1066.

Sahoo S, Chakraborti CK, Mishra SC, Nanda UN, Naik S. (2011). FTIR and XRD investigations of some fluoroquinolones. International Journal of Pharmacy and Pharmaceutical Sciences, 3(3):165-170.

Sahoo, S., Chakraborti, C. K., Mishra, S. C., & Nanda, U. N. (2011). Scanning Electron Microscopy as an Analytical Tool for Particle Size Distribution and Aspect Ratio Analysis of Ciprofloxacin Mucoadhesive Polymeric Suspension. International Journal of Research and Reviews in Applied Sciences, 6(1), 94-100.

Ali, H. S., Aslam, J., Rasool, B., Khan, S. A. (2009). Effect of raw materials on drug release from developed ciprofloxacin tablets. Stamford Journal of Pharmaceutical Sciences. 2009, 2(2), 8-15.