Effect of Ethanolic Extract of Soursop Bark in Reducing Blood Sugar and Cholesterol Levels
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Abstract
This study aims to determine effect of the ethanolic extract of soursop stembarks in the increasing of blood glucose and cholesterol levels. Maceration technique has been used to extract the soursop stembarks with ethanol 96% as a solvent extraction. Furthermore, the ethanolic extract of soursop stembarks was prepared in a suspension form with Na CMC 0.5 % as a suspending agent. The suspension was administered orally at dose of 50, 100, 300, 1000 mg/kg BW daily to white male mice for seven days. The level of blood sugar and cholesterol were measured at 8th day using digital tools Nesco®Multicheck. The result showed that the blood glucose level in mice at dose of 50, 100, 300, 1000 mg/KgBW were 123.25, 129.75, 132.25, 121.25 mg/dl. The cholesterol level mice at dose of 50, 100. 300, 1000 mg/kg BW were 156.5, 118.5, 149.75, 156.75 mg/dl respectively. Biostatistically, the ethanolic extract of soursop stembark showed the decreasing of cholesterol level significantly (p <0.05), but not significant to reduce the blood glucose level (p >0.05).
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References
Taylor, L. (2005). Graviola. The Healing Power of Rainforest Herbs. Square One Publishers; 2-3.
Departemen Kesehatan Republik Indonesia. (2007). Farmakope Indonesia (edisi IV). Jakarta: Departemen Kesehatan Republik Indonesia.
Ariyanti, Rina, Nurcahyanti W. dan Afifah S. (2007). Pengaruh Pemberian Infusa Daun Salam (Eugenia poliyanta Wight) Terhadap Penurunan Kadar Asam Urat Darah Mencit Putih Jantan yang Diinduksi dengan Potassium Oxonat, Pharmacon (8), 56-63.
Dipiro, Joseph T., Robert L. Talbert, Gary R. Matzke, Barbara G dan, Wells, L. Michael Posey. (2008). Pharmacoterapy: A Pathophysiologic Approach 7th Edition. USA: Medical Publishing Division.
Ganong, W. (2003). Fisiologi Kedokteran. Jakarta: Penerbit Buku Kedokteran EGC
Wild S, Roglic G, Green A, Sicree R, King H. (2004). Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care; 27: 1047–105
Cos, P., Calomme, M., Sindambiwe, J.B., Bruyne, T.D., Cimanga, K., Pieters, L., Vlietinck, A.J., dan Berghe, D.V., (2001), Cytotoxicity and Lipid Peroxidation-Inhibiting Activity of Flavonoids, Planta Med, 67, 515-519.
Adewole, Stephen O. dan John A. O. Ojewole. (2009). Protective Effect of Annona muricata Linn. (Annonaceae) Leaf Aqueous Extract on Serum lipid Profiles and Oxidative Stress in hepatocytes of Streptozotocin-Treated Diabetic Rats, Afr. J. Traditional, Complementary and Alternative Medicines, 6, 30-41.
Rengga puspita, R. (2007). Isolasi Triterpenoid dari kulit batang sirsak (Annona Muricata Linn) pada fraksi etil asetat terhadap uji “brine shrimps Lethality bioassayâ€. Unand : Fakultas Matematika dan Ilmu Pengetahuan Alam
Orlando Vieira de Sousa, Glauciemar Del-Vechio Vieira, Jose de Jesus R. G. de Pinho, Cella Hitomi Yamamoto dan, Maaria Silvana Alves. (2010). Antinociceptive and Anti-Inflamtory Acyivities of the ethanol Extract of Annona Muricata Linn. Leaves in Animal Models, International Journal of Molecular Sciences, 2067-2078.