Efek Proteksi Disfungsi Sel Endotel Ekstrak Terpurifikasi Daun Surian (Toona sureni BL. Merr) yang Diinduksi dengan Larutan NaCl 3 % Pada Mencit Jantan

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Published: May 29, 2019
DOI: https://doi.org/10.25077/jsfk.6.1.69-77.2019
Keywords:
Ekstrak terpurifikasi, T sureni, disfungsi sel endotel, NaCl, Nitric Oxyde.

Main Article Content

Suhatri Suhatri
Fakultas Farmasi Universitas Andalas
Amri Bachtiar
Fakultas Farmasi Unand
Ani Puji Astuti
Fakultas Farmasi Unand

Abstract

Lapisan endotelium terdiri dari satu lapisan sel endotel yang melapisi dinding vaskular yang menghadap ke lumen. Sel endotel menghasilkan mediator vasoaktif Endothelium Derived Relaxing Factor (EDRF) yaitu nitrogen monoksida (NO). Disfungsi sel endotel ditunjukkan dengan rendahnya kadar NO dan dapat menyebabkan hipertensi. Pada penelitian ini diteliti disfungsi sel endotel pada mencit putih jantan. Disfungsi sel endotel diinduksi dengan pemberian NaCl 3 %. Pada penelitian ini digunakan dosis ekstrak terpurifikasi daun Toona sureni (5, 10, 20) mg/kg BB yang diberikan secara oral selama 21 hari bersamaan dengan NaCl.  Para meter yang diamati  adalah  kadar  NO dalam serum. Hasil penelitian menunjukan  bahwa pemberian ekstrak terpurifikasi daun T sureni terbukti dapat memproteksi disfungsi sel endotel diinduksi NaCl 3 %, ditandai dengan meningkatkan kadar nitrogen monoksida mencit putih jantan dibandingkan kadar NO mencit kontrol positif (hanya diberi NaCl 3 %) dan berbeda nyata p < 0,05.

Article Details

How to Cite
Suhatri, S., Bachtiar, A., & Astuti, A. P. (2019). Efek Proteksi Disfungsi Sel Endotel Ekstrak Terpurifikasi Daun Surian (Toona sureni BL. Merr) yang Diinduksi dengan Larutan NaCl 3 % Pada Mencit Jantan. Jurnal Sains Farmasi & Klinis, 6(1), 69–77. https://doi.org/10.25077/jsfk.6.1.69-77.2019
Issue
Vol. 6 No. 1 (2019): J Sains Farm Klin 6(1), April 2019
Section
Research Articles

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Author Biography

Suhatri Suhatri, Fakultas Farmasi Universitas Andalas

Dosen bidang Farmakologi di Fakultas Farmasi Universitas Andalas.

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