Optimasi Formula Submikro Partikel Poly (Lactic-co-Glycolic Acid) Pembawa Betametason Valerat dengan Variasi Konsentrasi Poly (Vinyl Alcohol) dan Waktu Sonikasi

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Published: Apr 30, 2018
DOI: https://doi.org/10.25077/jsfk.5.1.55-65.2018
Keywords:
betamethasone valerate, optimization, Submicro particles, PLGA, PVA, sonication time.

Main Article Content

Mardiyanto Mardiyanto
Faculty of Mathematics and Science
Najma Anuria Fithri
Faculty of Mathematics and Science
Winesfin Raefty
Faculty of Mathematics and Science

Abstract

Preparation of betamethasone valerate (BMV) into submicro particle aims to resolve the solubility problem (Biopharmaceutics Classification System II) and to increase penetration through the skin. The method of emulsion solvent evaporation is used in preparing BMV encapsulated by PLGA (Poly (Lactic-co-Glycolic Acid) as polymer and PVA Poly (Vinyl Alcohol) as stabilizer. The proportion of optimum formula components obtained were 50 mg PVA and 10 minutes sonication time with the response values which resulted %EE of 73.000%, pH of 4.800, and %weight of BMV on stability test of 62.057%.The resulting diameter, PDI (poly dispersity ndex), and zeta potential analysis of the optimum formula were 342.700 nm, 0.104, and -12.200 mV respectively. Result from the particle morphology using Transmission Electron Microscopy showed spheric shape particle. The diffusion test showed the highest diffusion percent value on submicro particles of PLGA-BMV (23.067% ± 0.055) compared with pure BMV (18.007% ± 0.002) and comercial BMV cream (19.506%± 0,071). Analysis of the dissolution rate showed that submicro particles of PLGA-BMV (84.211% ± 1.943) increased the amount of drug released compared to pure BMV (10.912% ± 0.246). The release rate and mechanism of PLGA-BMV followed zero order.

Article Details

How to Cite
Mardiyanto, M., Fithri, N. A., & Raefty, W. (2018). Optimasi Formula Submikro Partikel Poly (Lactic-co-Glycolic Acid) Pembawa Betametason Valerat dengan Variasi Konsentrasi Poly (Vinyl Alcohol) dan Waktu Sonikasi. Jurnal Sains Farmasi & Klinis, 5(1), 55–65. https://doi.org/10.25077/jsfk.5.1.55-65.2018
Issue
Vol. 5 No. 1 (2018)
Section
Research Articles

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Author Biographies

Mardiyanto Mardiyanto, Faculty of Mathematics and Science

Dosen dengan tugas tambahan sebagai Ketua Jurusan Farmasi FMIPA Universitas Sriwijaya. Lektor, Penata gol III c

Najma Anuria Fithri, Faculty of Mathematics and Science

Dosen muda pada bidang teknologi farmasi di Jurusan Farmasi Universitas Sriwijaya dengan pangjat penata muda tingkat I/III b

Winesfin Raefty, Faculty of Mathematics and Science

Assisten dosen di Jurusan Farmasi FMIPA UNSRI

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