Solubilization of Parasetamol With Ryoto® Sugar Ester and Propylenglikol
Article Sidebar
Main Article Content
Abstract
Paracetamol was an active ingredient, which is poorly soluble in water. Absorption of poorly soluble or slightly soluble in water is influenced by the rate of dissolution. Solubilization is an alternative to improve drug solubility in water with the addition of surfactant. The addition of Ryoto® sugar ester surfactant and propylene glycol cosolvent conducted to determine the concentration of Ryoto® sugar ester and prophylene glycol that increase the solubility and stability of the dosage form. Solubilization of Paracetamol with the addition of Ryoto® sugar ester without propylene glycol and combinations Ryoto® sugar ester and propylene glycol at a concentration below the CMC point (Critical Micell Concentration), at the point of CMC, and above the CMC points in a row is 0.005 mg/ml, 0.006 mg/ml, and 0.007 mg/ml with 10% propylene glycol. The highest solubility of Paracetamol achieved in the formula 7 with a combination of the addition Ryoto® sugar ester (0.007 mg/ml) and propylene glycol (10%) by the recovery percentage of 99.6%, and the combination is also obtained the best preparation stability which is not occur the color change in the preparations during storage at room temperature and place protected from direct sunlight for a month. The addition of Ryoto® sugar ester surfactant and propylene glycol increase the solubility and stability of the solubilization of Paracetamol preparations.
Article Details
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Departemen Kesehatan Republik Indonesia. 1995. Farmakope Indonesia (Edisi IV). Jakarta: Dirjen POM Departemen Kesehatan Republik Indonesia.
Ansel, H. C. 1989. Pengantar Bentuk Sediaan Farmasi (Edisi IV). Penerjemah: F. Ibrahim. Jakarta: Universitas Indonesia Press.
Swarbrick, J. & Boylan, J. C. 1996. Encyclopedia of Pharmaceutical Technology, Volume 14. New York: Marcel Dekker
Lachman, L., Lieberman, H. A., Kanig, J. L. 1994. Teori dan Praktek Farmasi Industri, (3rd ed). Penerjemah: S. Suyatmi. Jakarta: Universitas Indonesia Press.
Voight, R. 1994. Buku Pelajaran Teknologi Farmasi (Edisi V). Penerjemah : Soedani Noerono. Yogyakarta : Gadjah mada University Press.
Martin, A. N, J.Swarbick, & A. Cammarata. 1993. Farmasi Fisik 2 (Edisi III). Penerjemah: Yoshita. Jakarta: Unversitas Indonesia Press.
Shargel L., Wu Pong, S., & Yu, A.B. C. 1999. Apllied Biopharmaceutics and Pharmacokinetics (5 th Ed). Singapore: MC. Graw and Hill.
Baker, I. J. A., Matthews, B., Suares, H., Krodkiewska, I., Furlong, N., Franz, G. Drummond, C. J. 2000. Sugar fatty acid ester surfactant: Structure and ultimate aerobic biodegradability. J. Surfactants Detergents, 3, 1-13.
Mitsubishi-Kagaku Food Corporation. 1982. Ryoto Sugar Ester Technical Information, Nonionic Surfactant/Sucrose Fatty Acid Ester/Food Additive.
Garti N., Aseri A., Faunn M. 2000. Nonionic Sucroce Ester Microemulsions for Food Applications. Part 1. Colloids Surf. A., 164, 27-38.
De Schaefer, C.R., de Ruiz Holgado, M .E.F., Arancibia, E. L. 2002. Solubility Parameters, Hydrophile-Lipophile Balance, and solubility in Sucrose Derivative Surfactants Obtained by GLC. J. Arg. Chem. Soc –Vol. 90 - N° 4/6, 55-63.
Halim, A., Hosiana, V., Elvita, L. 1997. Pengaruh Pemakaian Propilenglikol dan NaCl terhadap Solubilisasi Kofein dalam Larutan Air-Brij 35, J. Sains. Tek. Far., 2, 64 – 72.
Lin, C. M., Geng-pei Chang, Heng-kwong Tsao, Yu-jaene Sheng. 2011. Physics Solubilization Mechanism of Vesicles by Surfactants: Effect of Hydrophobicity. J Chem Phys, 135(4) 045102.