The bacterial contamination on the intravenous admixtures in a hospital treatment ward

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Published: Apr 30, 2018
DOI: https://doi.org/10.25077/jsfk.5.1.7-11.2018
Keywords:
bacterial contamination, intravenous admixture, sterility test

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Shinta Sari Dewi
Magister Clinical Pharmacy, Gadjah Mada University
Fita Rahmawati
Magister Clinical Pharmacy, Gadjah Mada University
Sylvia Utami Utami Tunjung Pratiwi
Magister Clinical Pharmacy, Gadjah Mada University

Abstract

Administration of intravenous admixtures with bacterial contamination during preparation and injection to the patient can cause nosocomial infection. The purpose of this study is to determine the frequency of bacterial contamination and the types of the bacteria which contaminate to the intravenous admixtures. The sampling was carried out in the treatment ward, Government Hospital in Yogyakarta. The bacterial contamination was determined by using sterility test with direct inoculation method. A total of 60 intravenous admixtures were collected consisting of 43 intravenous admixtures were prepared by nurse in treatment ward and 17 intravenous admixtures were prepared by pharmacist in clean room. The frequency of bacterial contamination was identified in 1 of 43 (2.3%) prepared in treatment ward and none of the intravenous admixtures (0%) prepared in clean room. Enterobacter cloacae and Staphylococcus aureus were detected in one sample. Although sanitation and the training of aseptic technique can reduce the risk of bacterial contamination in treatment ward, but by using clean room to prepare intravenous admixtures can be the best strategy

Article Details

How to Cite
Dewi, S. S., Rahmawati, F., & Tunjung Pratiwi, S. U. U. (2018). The bacterial contamination on the intravenous admixtures in a hospital treatment ward. Jurnal Sains Farmasi & Klinis, 5(1), 7–11. https://doi.org/10.25077/jsfk.5.1.7-11.2018
Issue
Vol. 5 No. 1 (2018)
Section
Research Articles

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Author Biography

Shinta Sari Dewi, Magister Clinical Pharmacy, Gadjah Mada University

Mahasiswi Magister Farmasi Klinik Universitas Gadjah Mada

References

Departemen Kesehatan Republik Indonesia. Pedoman Dispensing Sediaan Steril [Internet]. Departemen Kesehatan Republik Indonesia; 2009. Available from: https://binfar.kemkes.go.id/

Sharma M, Cheung JK, Dabbara A, Petersen J. Intravenous Admixture Compatibility for Sterile Products: Challenges and Regulatory Guidance. In: Sterile Product Development [Internet]. Springer, New York, NY; 2013 [dikutip 9 Januari 2018]. hlm. 461–74. (AAPS Advances in the Pharmaceutical Sciences Series). Available from: https://link.springer.com/chapter/10.1007/978-1-4614-7978-9_17

Poretz DM, Guynn JB, Duma RJ, Dalton HP. Microbial contamination of glass bottle (open-vented) and plastic bag (closed-nonvented) intravenous fluid delivery systems. Am J Hosp Pharm. 1974;31(8):726–732.

Khalili H, Sheikhbabayi M, Samadi N, Jamalifar H, Dalili D, Samadi N. Bacterial contamination of single-and multiple-dose vials after multiple use and intravenous admixtures in three different hospitals in iran. Iran J Pharm Res IJPR. 2013;12(1):205-209.

Motamedifar M, Askarian M. The prevalence of multidose vial contamination by aerobic bacteria in a major teaching hospital, Shiraz, Iran, 2006. Am J Infect Control. 2009;37(9):773–777.

Dik J-WH, Dinkelacker AG, Vemer P, Lo-Ten-Foe JR, Lokate M, Sinha B, dkk. Cost-Analysis of Seven Nosocomial Outbreaks in an Academic Hospital. PLOS ONE. 2016;11(2):1-7.

Mattner F, Gastmeier P. Bacterial contamination of multiple-dose vials: a prevalence study. Am J Infect Control. 2004;32(1):12–16.

Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian Di Rumah Sakit [Internet]. 2016. Available from: https:// binfar.kemkes.go.id/

Sandle T. Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals: Technology, Validation and Current Regulations. Elsevier; 2013. p.1-362

Davin A, Pages J-M. Enterobacter aerogenes and Enterobacter cloacae; versatile bacterial pathogens confronting antibiotic treatment. Front Microbiol. 2015;6:1–10.

Khan HA, Ahmad A, Mehboob R. Nosocomial infections and their control strategies. Asian Pac J Trop Biomed. 2015;5(7):509–514.

Mezzatesta ML, Gona F, Stefani S. Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance. Future Microbiol. 2012;7(7):887–902.

Austin PD, Hand KS, Elia M. Systematic review and meta-analysis of the risk of microbial contamination of parenteral doses prepared under aseptic techniques in clinical and pharmaceutical environments: an update. J Hosp Infect. 2015;91(4):306–318.

Baniasadi S, Dorudinia A, Mobarhan M, Karimi Gamishan M, Fahimi F. Microbial contamination of single- and multiple-dose vials after opening in a pulmonary teaching hospital. Braz J Infect Dis. 2013;17(1):69–73.

Macias AE, Huertas M, de Leon SP, Munoz JM, Chavez AR, Sifuentes-Osornio J, dkk. Contamination of intravenous fluids: a continuing cause of hospital bacteremia. Am J Infect Control. 2010;38(3):217–221.

Thomas M, Sanborn MD, Couldry R. I.V. admixture contamination rates: Traditional practice site versus a class 1000 cleanroom. Am J Health Syst Pharm. 2005;62(22):2386–2392.