Immunomodulatory Activity of Meniran Extracts (Phyllanthus niruri Linn.) on Broiler Chickens

Abstract

Broilers chickens are highly susceptible to many diseases caused by bacteria and viruses. Therefore to solve these problem we can use alternative medicine by administration of immunostimulatory compounds that can prevent disease in broiler chickens. One of the plants that can enhance the immune system is meniran. The study effect of immunomodulatory test from ethanol extract of meniran herbs (Phyllanthus niruri Linn.) has been conducted in broiler chickens with carbon clearance method. The study of extract administered orally with dose of 10; 30; 100; 300 mg/kg BW and a solution of 0.5% NaCMC as negative control also suspension Stimuno® forte 13.5 mg/kg BW as positive control for 6 days. The data of phagocytosis index was analyzed statisticaly with two way ANOVA followed with Duncan’s test. The increasing of phagocytosis index with carbon clearance method showed the effect from each dose with negative control was significant (P<0,05). The highest phagocytic index obtained from a dose of 300 mg / kg BW. The data’s of increased relative spleen weight and an increased of blood limfosit cell was analyzed statisticaly with one way ANOVA followed with Duncan’s test. Increased relative spleen weight and an increased of blood limfosit cell showed effect from each dose to negative control was significant (P<0,05). The results indicated that the ethanolic extract of meniran was active as immunostimulant for broiler chickens.