Protection Effect of Ethyl Acetate Fraction of Toona sureni (Blume) Merr. Against Atherosclerosis
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Published:
Nov 24, 2014
Keywords:
ethyl acetate fraction, toona sureni, atherosclerosis, hypercholesterolemia.
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Abstract
A study of the protection effect of ethyl acetate fraction of toona leaves (Toona sureni (Blume) Merr.) to the atherosclerotic blood vessel on the hypercholesterolemic quails has been carried out. The observation was conducted for histopathology of the blood vessel. The hypercholesterolemic quails were obtained through high-fat diet and propylthiouracil (PTU) induction. Aortic wall thickness, changes on the aortic lumen are, and visual endothelial cell dysfunction were determined. The study showed that the ethyl acetate fraction of toona leaves on the dose of 50 mg/kg body weight exhibited the best protection effect, indicated by aortic wall thickness and lumen area, and the degree of endothelial cell dysfunction which were not significantly different with the negative control group (p>0.05), but significantly different with positive control group (p<0.05).
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How to Cite
Suhatri, S., Marusin, N., Yeni, D., & Yosmar, R. (2014). Protection Effect of Ethyl Acetate Fraction of Toona sureni (Blume) Merr. Against Atherosclerosis. Jurnal Sains Farmasi & Klinis, 1(1), 10–19. https://doi.org/10.29208/jsfk.2014.1.1.20
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Research Articles
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Ifmaily. (1996). Isolasi Flavonoid dari Daun Surian (Toona sureni BL. Merr) (Skripsi sarjana farmasi). FMIPA Universitas Andalas. Padang.
Kraus, W. (1982). Surenone, surenine and surenolacton, three model tetranortriterpenoid from Toona sureni BL. Merr. Tetrahedron letter No. 29.
Ekaprasada, M. T., Nurdin, H., Ibrahim, S., & Dachriyanus, D. (2010). Antioxidant activity of methyl gallate isolated from the leaves of Toona sureni. Indonesian Journal of Chemistry, 9(3), 457-460.
Suhatri, Arifin H., & Irma, H. F. L. (2009). Efek proteksi ekstrak daun surian (Toona sureni BL. Merr) terhadap gangguan fungsi sel endotel pembuluh darah tikusâ€, Jurnal Sains dan Teknologi Farmasi, 14(2), 17-24.
Romy. (2009). Uji Aktivitas Antioksidan dari Ekstrak Etanol dan Hasil Fraksinasi Daun Surian (Toona sureni BL. Merr) secara in-vitro (Skripsi sarjana farmasi). Fakultas Farmasi, Universitas Andalas. Padang.
Iman, S. (2004). Serangan jantung dan stroke (edisi II). Jakarta: Gramedia Pustaka Utama.
8. Guyton, A. C., & Hall J. E. (2006). Medical physiology (11th ed). Phyladelphia: Elsevier Saunders Company.
Price, S. A., & Lorraine. (2006). Patofisiologi konsep klinis proses-proses penyakit (ed 6). Jakarta: Penerbit Buku Kedokteran EGC.
Whang, W. K., Park, H. S., Ham, I., Oh, M., Namkoong, H., Kim, H. K., ... & Kim, J. W. (2005). Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress. Experimental and molecular medicine, 37(4), 343.
Reiterer, G., Toborek, M., & Hennig, B. (2004). Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. The Journal of nutrition, 134(4), 771-775.
Prasetyo, A., Udadi, S., & Ika, P. M. (2000). Profil lipid dan ketebalan dinding arteri abdominalis tikus wistar pada injeksi inisial adrenalin intra vena dan diet kuning telor intermitten. Media Medika Indonesia, 35(3), 149-157.
Sofia, Dinna. (2005). Antioksidan dan Radikal Bebas. Diakses 25 Desember 2010 dari http://www. khasiat antioksidan/radikal bebas.
Kiernan J. A. (1990). Histological & histochemical methods: Theory and practice. New York: Pergamon Press.