Analgesic activity of Ethanolic Extract of Voacanga foetida (Bl.) K. Schum) on Male Mice
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Published:
Nov 24, 2014
Keywords:
analgesic, voacanga foetida, writhing test.
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Abstract
A study on the analgesic activity ethanolic extract of Voacanga foetida leaves has been conducted on male mice by using Writhing test. The mice were induced with 0.1 mL of glacial acetic acid 1%. The extract was administered orally in the doses of 250, 500, and 1000 mg/kg, suspended with NaCMC 1%, while 65 mg/kg acetosal was used as positive control. The data was analyzed with two way ANOVA. The study revealed that the extract exhibited analgesic effect insignificantly different with acetosal at the doses of 250, 500, and 1000 mg/kg. This effect was different with negative control (p<0.05).
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How to Cite
Susanty, A., Fernando, A., & Adelin, I. (2014). Analgesic activity of Ethanolic Extract of Voacanga foetida (Bl.) K. Schum) on Male Mice. Jurnal Sains Farmasi & Klinis, 1(1), 1–9. https://doi.org/10.29208/jsfk.2014.1.1.19
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Research Articles
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Valkenburg Van J. L. & Bunyaprapatsara. (2008). Medicinal and poisonous plants. Academic Press.
Pratama, M. (2009). Efek antiinflamasi ekstrak etanol daun tampa badak (Voacanga foetida (Bl.) K. Schum) pada tikus putih jantan (Rattus norvegicus) (Karya tulis ilmiah), Sekolah Tinggi Ilmu Farmasi Riau.
Suryati. (2010). Uji efek antiinflamasi fraksi heksan daun tampa badak (Voacanga foetida) pada tikus putih jantan (Rattus norvegicus) (Karya tulis ilmiah). Sekolah Tinggi Ilmu Farmasi Riau.
Lovena, T. N. (2010). Uji efek antiinflamasi fraksi etil asetat daun tampa badak (Voacanga foetida (Bl.) K. Schum) pada tikus putih jantan (Rattus norvegicus) (Karya tulis ilmiah). Sekolah Tinggi Ilmu Farmasi Riau.
Bingtao Li, Antony J. M., Leeuwenberg & David J. Middleton. Apocynaceae, in Flora of China Vol. 16 Page 143. Published by Science Press (Beijing) and Missouri Botanical Garden Press
Kunesch, N., Das, B. C., & Poisson, J. (1970). Alcaloides des Voacanga. XI. Structure des bases bis-indoliques des feuilles du Voacanga africana Stapf. Soc Chim France Bull.
Macabeo, A. P. G., Alejandro, G. J. D., Hallare, A. V., Vidar, W. S., & Villaflores, O. B. (2009). Phytochemical survey and pharmacological activities of the indole alkaloids in the genus Voacanga Thouars (Apocynaceae)-an update. Pharmacognosy Reviews, 3(5), 132-142.
Anonim, (1979). Farmakope Indonesia, Edisi III, Departemen Kesehatan Republik Indonesia, Direktorat Jenderal Pengawasan Obat dan Makanan, Jakarta.
Thompson, E. B. (1985). Drugs bioscreening fundamental of drug, evaluation technique in pharmacology. New York: Granceway Publising Company.
Turner, R. A. (1965). Screening methods in pharmacology. New York and London: Academic Press,
Martindale. (2002). The complete drug reference, (thirty third edition). London: The Pharmaceutical Press.
Ganiswarna, S. G. (2007). Farmakologi dan terapi (edisi V). Jakarta: Gaya Baru.
Wilmana, P. F. (2005). Analgesik-Antipiretik Analgetik Antiinflamasi Non Steroid dan Obat Pirai, Farmakologi dan Terapi (edisi IV). Jakarta: Universitas Indonesia.
Harmita & Radji. M. (2008). Buku ajar analisis hayati (edisi 3). Jakarta: Penerbit Buku Kedokteran EGC.