Formulation of Ranitidine HCl Microcapsules with Ethyl Cellulose Using a Factorial Design
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Abstract
Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours.
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References
Benita, S. (2006). Microencapsulation Methods and Industrial Application (second edition). New York: Marcel Dekker Inc.
Sweetman.S.C. (2009). Martindale The Complete Drug Reference (Edisi 36). London: Pharmaceutical Press.
Anderson, P.O., Knoben, J.E., Troutman, W.G. (2002). Handbook of Clinical Drug Data (10thed). New York: McGraw-Hill.
Wells, B. G., DiPiro, J. T., Schwinghammer, T. L., Hamilton, C. W. 2006. Pharmacotherapy Handbook (6th ed). Singapore: McGraw-Hill.
Punitha, K., Khadhir, S., Ravichandiran, V., Umadevi, S. K., Vaijayanthi, V., Padmapriya, S., Suresh, K. S. (2010). Intragastric Floating Drug Delivery System of Ranitidine Hydrochloride: Formulation and Evaluation. International Journal of Pharmacy and Pharmaceutical Sciences, 2(4), 105-108.
Voigth, R. (1994). Buku Pelajaran Teknologi Farmasi. (Edisi 5). Penerjemah: Soendani Noerono. Yogyakarta: Gajah Mada University Press.
United States Pharmacopoeial Convention. (2007). United states of pharmacopoeia (30th ed.). New York: United States Pharmacopoeial Convention Inc.
Depkes RI. (1995). Farmakope Indonesia. (Edisi 4). Jakarta: Departemen Kesehatan Republik Indonesia.
British Pharmacopoeia Commision. British Pharmacopoeia. (2008). London: Pharmaceutical Press.
Carstensen, J. T. (2001). Advanced Pharmaceutical Solids. New York: Marcel Dekker.
Rosca, D. I., Watari, F., Uo, M., Akasaka, T., Tamura, K. Mechanism of Biodegradable Polymer Microparticle Formation by Emulsification Solvent Evaporation Method. Hokkaido University, 87-92.
Roy, S., Panpalia, S. G., Nandy, B. C., Rai, V. K., Tyagi, L. K., Dey, S., Meena, K. C. (2009). Effect of Method of Preparation on Chitosan Microspheres of Mefenamic Acid. International Journal of Pharmaceutical Sciences and Drug Research, 1(1), 36-42.
Costa, P., Lobo, J. M. S. (2001). Modeling and Comparison of Dissolution Profiles. European Journal of Pharmaceutical Sciences, 13, 123-133.