Off-label drug use for children at community pharmacies in Yogyakarta, Indonesia
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Abstract
Population of children is at risk of getting off-label medication because of its particular condition. This study was conducted to find out how the prevalence of off-label drug use for children at community pharmacies in Yogyakarta. This was a retrospective, medical record-based study using the 2014-2015. The study subjects consisted of children under 12 years old. About 828 prescriptions were reviewed, 268 were included accord with completeness diagnose data in patients medical records. The accumulative of drug use among 268 prescriptions were 816 drugs use with 76 item drugs. We have identified 268 prescriptions, of those 268 prescriptions, we found off label drugs in 57 prescriptions (21%). identified, off-label use accounted for 57 prescriptions (21%). The prevalence of off-label use classified as off-label age accounted for 91 use (11.1%); off-label indications accounted for 7 use (0.8%); and did not find off-label category dosage, route of administration and contraindication. The three highest use off-label drugs respectively pseudoephedrine accounted for 47 (5.7%), tripolidine 20 (2.4%), and dextromethorphan 14 (1.7%) of all drug use. Based on the results of this study, we found that the use of off-label drugs in children is quite high (21%) so that supervision-related risks of drug use need to be done.
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