Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation

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Published: Apr 9, 2025
DOI: https://doi.org/10.25077/jsfk.11.3.197-207.2024
Keywords:
oil, seed, Helianthus annuus L., serum, Propionibacterium acnes

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Soraya Ratnawulan Mita Mita
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
Sri Agung Fitri Kusuma
2Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
Devani Olivia Winardi
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
Patihul Husni
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
Yoshihito Shiono
Department of Food, Life, and Environmental Sciences, Faculty of Agriculture, Yamagata University, Yamagata 997-8555, Japan

Abstract

Acne is caused by a microbial imbalance due to the overgrowth of Propionibacterium acnes in the skin microbiome. Sunflower seed oil (Helianthus annuus L.), which contains linoleic acid and terpenoids, has an antibacterial activity against P. acnes. This study aimed to increase the availability of anti-acne compounds from natural resources by formulating an anti-acne serum containing sunflower seed oil. The research methods included antibacterial activity testing of sunflower seed oil, serum formulation, product evaluation, and serum effectiveness testing. The results of the antibacterial activity test of sunflower seed oil against P. acnes ATCC 6919 showed a minimum inhibitory concentration (MIC) of 100 mg/mL and a minimum bactericidal concentration (MBC) of 200 mg/mL. The result of serum evaluation and stability testing during the freeze-thaw cycling test depicted stable formulation for all formulas based on organoleptic parameters, homogeneity, pH, viscosity, and spreadability. The effectiveness test results of the serum preparation showed that formula 3, containing 200 mg/L of sunflower seed oil, was the best formula with an inhibition zone diameter of 12.76 ± 0.03 mm. In conclusion, sunflower seed oil demonstrates the ability to prevent and treat acne-prone skin, making it a suitable alternative anti-acne compound.


 

Article Details

How to Cite
Mita, S. R. M., Sri Agung Fitri Kusuma, Devani Olivia Winardi, Patihul Husni, & Yoshihito Shiono. (2025). Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation. Jurnal Sains Farmasi & Klinis, 11(3), 197–207. https://doi.org/10.25077/jsfk.11.3.197-207.2024
Issue
Vol. 11 No. 3 (2024): J Sains Farm Klin 11(3), December 2024
Section
Research Articles
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