Preparation and Characterization of Multicomponent Crystal Piperine-Caffeine

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Published: Dec 29, 2023
DOI: https://doi.org/10.25077/jsfk.10.3.353-358.2023
Keywords:
piperine, caffeine, multicomponent crystal, solvent evaporation, solvent drop grinding

Main Article Content

Lili Fitriani
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, Indonesia
Clara Alverina Simbolon
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, Indonesia
Erizal Zaini
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, Indonesia

Abstract

Piperine (C17H19NO3) belongs to the alkaloid group mainly found in the Piperaceae family, especially in black pepper (Piper nigrum L.). Piperine is practically insoluble in water. This study aims to improve the solubility of piperine by preparing it into a multicomponent crystal using caffeine as a coformer. The formation of piperine-caffeine multicomponent was prepared by solvent evaporation and solvent drop grinding. Each sample was characterized using Powder X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), and FT-IR spectroscopy. The solubility test was carried out by sonication for 30 minutes at room temperature (30 â°C), and the dissolved piperine was analyzed by High-Performance Liquid Chromatography (HPLC) using methanol: water (80:20) as the mobile phase. This study shows a decrease in peak diffraction intensity on PXRD analysis and a reduction in endothermic peak on the DSC thermogram of multicomponent crystals. In the FTIR analysis, multicomponent crystals slightly shift, indicating the physical interaction. The multicomponent crystal of piperine-caffeine prepared by solvent evaporation method has an increase in solubility of 2.56 times, and the multicomponent crystal with solvent drop grinding method has an increase in solubility of 1.61 times, respectively. In conclusion, the multicomponent crystal piperine–caffeine can enhance the solubility of piperine.

Article Details

How to Cite
Fitriani, L., Simbolon, C. A., & Zaini, E. (2023). Preparation and Characterization of Multicomponent Crystal Piperine-Caffeine. Jurnal Sains Farmasi & Klinis, 10(3), 353–358. https://doi.org/10.25077/jsfk.10.3.353-358.2023
Issue
Vol. 10 No. 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Section
Research Articles
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