The Release of Ibuprofen from Carbomer 940 Gel of Ibuprofen- Nicotinamide Cocrystal
Article Sidebar
Main Article Content
Abstract
One of the methods to increase the solubility is co-crystalization. As Ibuprofen can be used in topical application for rheumatoid arthritis, a study about formulation and release of ibuprofen-nicotinamide co-crystal in carbomer gel had been conducted. Co-crystal was obtained from a dissolve method, which ibuprofen and nicotinamida were mixed with equimol composition (1:1). Gel consisted of two formulas with the same amount of ibuprofen (5%). The first formula was gel co-crystal ibuprofen-nicotinamide and the second formula was pure ibuprofen. The basis used was carbormer 940. The release test was done using the horizontal type of Franz diffusion cell and measured using HPLC (High Performance Liquid Chromatography) with mobile phase of methanol: aquabidest (80:20) pH 3.5 with orthophosphate acid. The results showed both formulas were not stable in homogeneity aspect for several storage days. Separation was occurred at low and high temperatures. The result of release profiles at the 120th minutes was 4.4793 % and 4.4293 % and the release efficiencies were 3.8891 and 3.8612. The statistic analysis showed that release efficiencies of both formulas were not significantly different (p>0.05) using One-Way ANOVA. In a conclusion, the process of making gel of co-crystal ibuprofen-nicotinamide did not influenced ibuprofen release in gel preparation.
Article Details
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Sweetman, S. C., (2009). Martindale: the complete drug reference (Edisi 36). London: Pharmaceutical Press.
Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia (Edisi IV). Jakarta. Depkes RI.
Zaini, E., Halim, A., Soewandhi, S. N. & Setyawan, D. (2011). Peningkatan laju pelarutan trimetoprim melalui metode kokristalisasi dengan nikotinamida. Jurnal Farmasi Indonesia, 5(4), 195-204.
Wouters, J., & Luc Q. (2011). Pharmaceutical Salts and Cocrystals. London: RSC Drug Discovery.
Fernandes, R. D. (2012). Pembuatan Kokristal Ibuprofen dan Nikotinamida dengan Metode Pemanasan Tertutup. (Skripsi). Padang: Universitas Andalas.
Firnandes, O. (2012). Pembuatan Kokristal Ibiprofen-Nikotinamid dengan Metode Solid State Grinding. (Skripsi). Padang: Universitas Andalas.
Pratiwi, W. (2013). Preparasi Tablet Kokristal Ibuprofen-Nikotinamida dan Evaluasi Laju Disolusinya. (Skripsi). Padang: Universitas Andalas
Harmita. (2004). Petunjuk Pelaksanaan Validasi Metode dan Cara Perhitungannya. Majalah Ilmu Kefarmasian, 1(3), 117-135.
Agustin, R., Agoes, G., & Susanti, T. (2007). Studi Pengaruh Komplek Siklodekstrin Terhadap Penetrasi Perkutan Piroksikam. Jurnal Farmasi Indonesia, 3(3), 111-118.
Ansel, H. C. (2005). Pengantar Bentuk Sediaan Farmasi (Edisi IV). Penerjemah: F. Ibrahim. Jakarta: UI Press.
Lachman, L., Lieberman, H. A., & Kang, J. L. (1994). The Theory & Practice of Industrial Pharmacy (2nd Edition). Philadelphia: Lea & Febringer.