Effectiveness of antibiotics in patients with diabetic foot ulcers
Article Sidebar
Main Article Content
Abstract
Patients with diabetic foot infection require antibiotics. Generally, antibiotics may have low sensitivity and some bacteria have been resistance to antibiotics. Currently, evaluating the effectiveness of antibiotics is necessary to avoid antibiotic resistance. This study has been conducted using the longitudinal method and prospective sampling technique. Observed parameters were leukocyte, signs of infection and fever after using antibiotics. The data collected were then analyzed to determine the effectiveness of antibiotics based on supporting literature. A number of 19 out of 28 samples of patients with diabetic foot ulcer met the criteria, consisting of 63.16% and 36.84% of male and female patients, respectively. Most of the patients (68,42%) were aged 45-60 years old living with diabetes for more than 10 years. The antimicrobial therapy were given empirically in 8 patients (42,10%) and based on microbial sensitivity (definitive) in 11 patients (57,89%). The use of antibiotics was effective in 15 patients (78,94%) marked by the leukocyte count, signs of infection and fever parameters after 2-3 days using antibiotics. The optimum therapeutic outcome was achieved in 7 to 21 days.
Article Details
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Brand, P. (2000). The foot in diabetic. Diabetes Mellitus. ADA. Premtice hal International. Maryland.
Hatanta, A. (2013). Kajian Penggunaan Antibiotik Pada Pasien Infeksi Ulkus Kaki Diabetik IRNA PD RSUP Dr. M. Djamil Padang. (Tesis). Universitas Andalas. Padang.
Ahmad, J. (2016). The Diabetic Food. Diabetes & Metabolic Syndrome: Clinical research & reviews, 10(1), 48-60.
Decroli, E., Jazil, K., Asman, M., & Syafril, S. (2008). Profil Ulkus Diabetik Pada Penderita Rawat Inap Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang. Majalah Kedokteran Indonesia, 58(1), 1-7.
Permenkes. (2011). Pedoman Umum Penggunaan Antibiotik. Kementrian Kesehatan RI. Jakarta.
Frieri, M., Kumar, K., Boutin, A. (2017). Antibiotic Resistance. Jurnal of Infection and Public Health, 10(4), 369-378.
Frykberb, R. (2002). Risk Factor, Pathogenesis and Management of Diabetic Foot Ulcers. Des Moines University. Lowa.
Wells, B., Dipiro, J., & Terry, L. (2009). Pharmacotherapy Handbook, Seventh Edition. The McGraw-Hill Companies. Inc. New York.
Rochman, W. (2009). Diabetes Millitus pada Usia Lanjut. Jilid III. Edisi kelima. Balai Penerbit FK UI. Jakarta.
Hastuti, Rini, T. (2007). Faktor-faktor Risiko Ulkus Diabetika pada Penderita Diabetes Millitus (Studi kasus di RSUD Dr. Moewardi Surakarta). (Tesis). Universitas Diponegoro. Semarang.
Misnadiarly. (2006). Diabetes Mellitus Gangren, Ulcer, Infeksi. Penerbit Populer Obor. Jakarta.
Guyton, A., & Hall, J. (2012). Buku Ajar Fisiologi Kedokteran. Edisi 11. Alih bahasa Irawati dkk. EGC. Jakarta.
Dipiro, J., Robert, L., Gary, C., & Barbara, G. (2006). Pharmacotherapy: A Pathophysiologic Approach. Sixth Edition. The McGraw-Hill Companies. Inc.
Goldman, D., & Huskins, W. (2000). Control of Nosocomial Antimicrobial Resistant Bacteria: Strategy Priority, Clinical Infectious Disease. New York.
Noor, S., Rizwan, U. K. & Jamal, A. (2017). Understanding Diabetic Foot Infection and its Management. Diabetes & Metabolic Sindrome: Clinical Research & Reviews, 11(2), 149-156.
Mary, T., Alicia, T. & Adolf, W. K. (2012). Diabetic Foot Infection. Hospital Medicine Clinics, 1(2), e185-e198.
Katzung, B., Susan, B., Masters., & Anthony, J. (2010). Basic  Clinical Pharmacologiy 10th ed. McGraw-Hill Companies. USA.
Frykberg, R., Zgonis, T., & David, G. (2006). Diabetic Foot Disorders a Clinical Practice Guideline, An official publication of the American College of Foot and Ankle Surgeons. USA.
Brunton, L., Keith., & Donald, L. (2010). Goodman & Gillman’s Manual of Pharmacology and Therapeutics. Diterjemahkan oleh July Manurung. ECG. Jakarta.
Kahuripan, A., Retnosari, A. (2009). Analisis pemberian antibiotik berdasarkan hasil uji sensitifitas terhadap pencapaian clinical outcome pasien infeksi ulkus diabetik di RSUD Dr. H. Abdul Moeloek Lampung. Majalah Ilmu Kefarmasian, 6(2), 75-87.