Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study

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Published: Apr 9, 2023
DOI: https://doi.org/10.25077/jsfk.10.1.21-27.2023
Keywords:
Diabetes Mellitus, medication adherence, HbA1c, Quality of Life (QoL)

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Delila Eliza
1. Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Nadia Farhanah Syafhan
1. Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia. 2. Unit of Pharmacy and Central Sterile Supply Department, Universitas Indonesia Hospital, Depok, Indonesia.
https://orcid.org/0000-0002-3535-0209
Retnosari Andrajati
1. Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia. 2. Unit of Pharmacy and Central Sterile Supply Department, Universitas Indonesia Hospital, Depok, Indonesia
https://orcid.org/0000-0003-1319-1240
Sri Wulandah Fitriani
2. Unit of Pharmacy and Central Sterile Supply Department, Universitas Indonesia Hospital, Depok, Indonesia

Abstract

Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diabetes Mellitus (DM). Studies on the relationship between medication adherence and blood sugar control on the quality of life (QoL) in Type 2 DM patients are limited in Indonesia. This study aims to assess the relation between medication adherence with blood sugar control and the quality of life of Type 2 DM patients. This study used a cross-sectional design conducted at Universitas Indonesia Hospital. It used Medication Adherence questionnaires and EuroQoL 5D-5L questionnaires to assess patients’ medication adherence and quality of life. This study involved a total of 74 Type 2 DM patients with an average age of 57 ± 10.74 years. Medication adherence with good blood sugar control (HbA1c <7%) showed a significant relationship (p-value <0.05) with COR values of 3.74 (1.21 - 11.6) compared to non-adherent patients. But not on the QoL Index and VAS (Visual Analog Scale) values, where the value is lower in patients with high adherence and good blood sugar control. Factor asscociated with blood sugar controlled were comorbidites and medication adhrence while factor that associated with quality of life were comorbidities, ages, education and employment status

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How to Cite
Eliza, D., Syafhan, N. F., Andrajati, R., & Fitriani, S. W. (2023). Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study. Jurnal Sains Farmasi & Klinis, 10(1), 21–27. https://doi.org/10.25077/jsfk.10.1.21-27.2023
Issue
Vol. 10 No. 1 (2023): J Sains Farm Klin 10(1), April 2023
Section
Research Articles
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References

. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. https://doi.org/10.1016/j.diabres.2019.107843

. Perkeni. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Di Indonesia 2021. PB PERKENI; 2021.

. Taylor SI, Yazdi ZS, Beitelshees AL. Pharmacological treatment of hyperglycemia in type 2 diabetes. J Clin Invest. 2021;131(2). https://doi.org/10.1172/JCI142243

. Melmer A, Laimer M. Treatment goals in diabetes. Endocr Dev. 2016;31:1–27. https://doi.org/10.1159/000439364

. Tsoutsouki J, Wunna W, Chowdhury A, Chowdhury TA. Advances in the management of diabetes: Therapies for type 2 diabetes. Postgrad Med J. 2020;96(1140):610–8. https://doi.org/10.1136/postgradmedj-2019-137404

. Pippit K, Li M, Gurgle HE. Diabetes Mellitus: Screening and Diagnosis. Am Fam Physician. 2016;93(2):103–9. Available from: https://pubmed.ncbi.nlm.nih.gov/26926406/

. Wong MCS, Wu CHM, Wang HHX, Li HW, Hui EMT, Lam AT, et al. Association between the 8-item Morisky medication adherence scale (MMAS-8) score and glycaemic control among Chinese diabetes patients. J Clin Pharmacol. 2015;55(3):279–87. https://doi.org/10.1002/jcph.408

. Soraya IA, Sauriasari R, Prawiroharjo P, Risni HW. The Association between Adherence to Oral Antihyperglycemic Agent and HbA1c Level. Pharm Sci Res. 2022;9(2):93–101. https://doi.org/10.7454/psr.v9i2.1260

. Ho PM, Rumsfeld JS, Masoudi FA, McClure DL, Plomondon ME, Steiner JF, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836–41. https://doi.org/10.1001/archinte.166.17.1836

. American Diabetes Association. Standards of Medical Care in Diabetes—2022 Abridged for Primary Care Providers. Clin Diabetes. 2022;40(1):10–38. https://doi.org/10.2337/cd22-as01

. Dhillon H, Nordin R Bin, Ramadas A. Quality of life and associated factors among primary care Asian patients with type 2 diabetes mellitus. Int J Environ Res Public Health. 2019;16(19). https://doi.org/10.3390/ijerph16193561

. Alfian SD, Sukandar H, Lestari K, Abdulah R. Medication Adherence Contributes to an Improved Quality of Life in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study. Diabetes Ther. 2016;7(4):755–64. https://doi.org/10.1007/s13300-016-0203-x

. Martínez Y V., Prado-Aguilar CA, Rascón-Pacheco RA, Valdivia-Martínez JJ. Quality of life associated with treatment adherence in patients with type 2 diabetes: A cross-sectional study. BMC Health Serv Res. 2008;8:1–10. https://doi.org/10.1186/1472-6963-8-164

. Riastienanda L, Zullies; I, Endarti D. Validasi 8-Item Morisky Medication Adherence Scale Versi Indonesia Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Kabupaten Sleman Dan Kota Yogyakarta. Univ Gadjah Mada. 2017; Available from: https://etd.repository.ugm.ac.id/penelitian/detail/109819

. Purba FD, Hunfeld JAM, Iskandarsyah A, Fitriana TS, Sadarjoen SS, Ramos-Goñi JM, et al. The Indonesian EQ-5D-5L Value Set. Pharmacoeconomics. 2017;35(11):1153–65. https://doi.org/10.1007/s40273-017-0538-9

. Arifin B, Idrus LR, van Asselt ADI, Purba FD, Perwitasari DA, Thobari JA, et al. Health-related quality of life in Indonesian type 2 diabetes mellitus outpatients measured with the Bahasa version of EQ-5D. Qual Life Res. 2019;28(5):1179–90. https://doi.org/10.1007/s11136-019-02105-z

. Tominaga Y, Aomori T, Hayakawa T, Morisky DE, Takahashi K, Mochizuki M. Relationship between medication adherence and glycemic control in Japanese patients with type 2 diabetes. Pharmazie. 2018;73(10):609–12. https://doi.org/10.1691/ph.2018.8587

. Ibrahim AO, Agboola SM, Elegbede OT, Ismail WO, Agbesanwa TA, Omolayo TA. Glycemic control and its association with sociodemographics, comorbid conditions, and medication adherence among patients with type 2 diabetes in southwestern Nigeria. J Int Med Res. 2021;49(10). https://doi.org/10.1177/03000605211044040

. Chew BH, Hassan NH, Sherina MS. Determinants of medication adherence among adults with type 2 diabetes mellitus in three Malaysian public health clinics: A cross-sectional study. Patient Prefer Adherence. 2015;9:639–48. https://doi.org/10.2147/PPA.S81612

. Al-Qazaz HK, Sulaiman SA, Hassali MA, Shafie AA, Sundram S, Al-Nuri R, et al. Diabetes knowledge, medication adherence and glycemic control among patients with type 2 diabetes. Int J Clin Pharm. 2011;33(6):1028–35. https://doi.org/10.1007/s11096-011-9582-2

. Zhang J, Yang C, Peng Y, Ni X. Association between medication adherence and health-related quality of life in patients with tic disorder: A cross-sectional survey. Neurol Asia. 2022;27(2):369–77. https://doi.org/10.54029/2022sju

. Khayyat SM, Mohamed MMA, Khayyat SMS, Hyat Alhazmi RS, Korani MF, Allugmani EB, et al. Association between medication adherence and quality of life of patients with diabetes and hypertension attending primary care clinics: a cross-sectional survey. Qual Life Res. 2019;28(4):1053–61. https://doi.org/10.1007/s11136-018-2060-8