Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) yang Memanfaatkan Tanaman Obat: Narrative Review

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Published: Aug 21, 2023
DOI: https://doi.org/10.25077/jsfk.10.2.184-196.2023
Keywords:
self-nanoemulsifying drug delivery system (SNEDDS), tanaman obat, ekstrak, kelarutan

Main Article Content

Nur Asita
Program Studi Magister Farmasi Univeritas Islam Indonesia
Muhammad Sulaiman Zubair
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Tadulako
Yandi Syukri
Universitas Islam Indonesia

Abstract

Pemanfaatan tanaman obat sebagai terapi pengobatan memiliki hambatan untuk sampai ke target aksi karena rendahnya kelarutan dan bioavaibilitas zat aktif dalam air. Self-Nanoemulsifying Drug Delivery System (SNEDDS) merupakan salah satu metode yang dikembangkan untuk meningkatkan kelarutan dan bioavaibilitas zat aktif termasuk ekstrak dari tanaman. Studi literatur ini bertujuan untuk mengkaji formula SNEDDS yang memanfaatkan tanaman obat dengan mengulas informasi yang dikumpulkan dari original article yang relevan. Penelusuran referensi dilakukan pada website seperti Google Scholar, Pub-Med dan ScienceDirect. Beberapa tanaman obat yang diformulasikan menjadi sediaan SNEDDS yaitu sirsak, grapefruits, beetroot, kunyit, propolis, daun salam, sarang semut, daun papaya, buah parijoto, pegagan, temulawak, kelor, ketepeng dan manggis menghasilkan karakteristik yang baik. Sediaan SNEDDS dari tanaman herbal tersebut memiliki nilai transmitan dari rentang 72,74% hingga 100%, waktu emulsifikasi pada sediaan kurang dari 5 menit, zeta potensial -0,2 mV hingga -56 mV. Nilai polydispersity index kurang dari 0,4 dan ukuran partikel yang kurang dari 100 nm. SNEDDS memiliki kemampuan untuk memperbaiki bioavaibilitas dan kelarutan dari senyawa sehingga menghasilkan aktivitas farmakologis yang lebih baik dibandingkan dengan pemberian ekstrak, fraksi maupun senyawa aktif yang tanpa menggunakan sistem penghantaran. Kemampuan SNEDDS dalam meningkatkan bioavaibilitas serta kelarutan senyawa dalam air yang menyebabkan aktivitas farmakologis menjadi semakin tinggi. Formulasi SNEDDS dapat meningkatkan aktivitas senyawa pada tanaman obat hal ini ditandai dengan peningkatan bioavaibilitas obat sehingga SNEDDS dapat menjadi alternatif untuk meningkatkan efisiensi penyembuhan suatu penyakit

Article Details

How to Cite
Asita, N., Zubair, M. S., & Syukri, Y. (2023). Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) yang Memanfaatkan Tanaman Obat: Narrative Review. Jurnal Sains Farmasi & Klinis, 10(2), 184–196. https://doi.org/10.25077/jsfk.10.2.184-196.2023
Issue
Vol. 10 No. 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Section
Review Articles
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Author Biography

Yandi Syukri, Universitas Islam Indonesia

Scopus ID : https://www.scopus.com/authid/detail.uri?authorId=57190751925 

Scholar ID : https://scholar.google.co.id/citations?hl=id&user=2U2o7NMAAAAJ

References

. WHO. WHO Global report on traditional and complementary medicine 2019. World Health Organization. 2019. Accessed: 18.12.2020.

. Nisar B, Sultan A, Rubab SL. Comparison of Medicinally Important Natural Products versus Synthetic Drugs-A Short Commentary. Nat Prod Chem Res. 2018;06(02). https://doi.org/10.4172/2329-6836.1000308

. Ruiz-Ruiz JC, Matus-Basto AJ, Acereto-Escoffié P, Segura-Campos MR. Antioxidant and anti-inflammatory activities of phenolic compounds isolated from Melipona beecheii honey. Food Agric Immunol. 2017;28(6):1424–37. https://doi.org/10.1080/09540105.2017.1347148

. Tagousop CN, Tamokou J de D, Kengne IC, Ngnokam D, Voutquenne-Nazabadioko L. Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes. Chem Cent J. 2018;12(1):1–9. https://doi.org/10.1186/s13065-018-0466-6

. Kuncoro H, Farabi K, Rijai L, Julaeha E, Supratman U, Shiono Y. Flavonoid compounds from krokot herb (Lygodium microphyllum) and their antioxidant activity against DPPH. J Math Fundam Sci. 2018;50(2):192–202. https://doi.org/10.5614/j.math.fund.sci.2018.50.2.7

. Nzogong RT, Ndjateu FST, Ekom SE, Fosso JAM, Awouafack MD, Tene M, et al. Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola. BMC Complement Altern Med. 2018;18(1):1–11. https://doi.org/10.1186/s12906-018-2229-2

. Rusli R, Ningsih BA, Rahmadani A, Febrina L, Maulidya V, Fadraersada J. Isolation and evaluation of antioxidant and antibacterial activity of flavonoid from ficus variegata blume. Indones J Chem. 2019;19(2):538–43. https://doi.org/10.22146/ijc.23947

. Dalimunthe A, Hasibuan PAZ, Silalahi J, Sinaga SF, Satria D. Antioxidant activity of alkaloid compounds from litsea cubeba lour. Orient J Chem. 2018;34(2):1149–52. https://doi.org/10.13005/ojc/340270

. Khumaidi A, Widodo A, Nugrahani AW, Sasmito E, Fakhrudin N. Profi l Proliferasi Sel Limfosit Benalu Batu ( Begonia medicinalis ) Asal Kabupaten Morowali Utara Provinsi Sulawesi Tengah. J Ilmu Kefarmasian Indones. 2020;18(1):61–7.

. Candra GNH, Wijaya IMAP. Molecular Docking Kaempferol sebagai Antiinflamasi pada Aterosklerosis secara In Silico. J Ilm Medicam. 2021;7(1):13–8. https://doi.org/10.36733/medicamento.v7i1.1497

. Purwanto DS, Susanti H, Sugihartini N. Docking Molekuler Potensi Anti Inflamasi Quersetin Daun Kelor (Moringa oleifera L.) dengan Autodock-Vina. J Ilm Mns Dan Kesehat. 2021;4(2):309–13.

. Setyawan D, Fadhil AA, Juwita D, Yusuf H, Sari R. Enhancement of Solubility and Dissolution Rate of Quercetin with Solid Dispersion System Formation Using Hydroxypropyl Methyl Cellulose Matrix. Thai J Pharm Sci. 2017;41(3):112–6.

. Kaur H, Kaur G. A Critical Appraisal of Solubility Enhancement Techniques of Polyphenols. J Pharm. 2014;2014:1–14. https://doi.org/10.1155/2014/180845

. Cadena PG, Pereira MA, Cordeiro RBS, Cavalcanti IMF, Barros Neto B, Pimentel MDCCB, et al. Nanoencapsulation of Quercetin and Resveratrol Into Elastic Liposomes. Biochim Biophys Acta - Biomembr. 2013;1828(2):309–16. https://doi.org/10.1016/j.bbamem.2012.10.022

. Harwansh RK, Deshmukh R, Rahman MA. Nanoemulsion: Promising Nanocarrier System for Delivery of Herbal Bioactives. J Drug Deliv Sci Technol. 2019;51(February):224–33. https://doi.org/10.1016/j.jddst.2019.03.006

. Mardiyanto, Untari B, Anjani R, Annuria NF. Solid Self Nano Emulsifying Drug Delivery System (Solid Snedds) of Mefenamic Acid: Formula Optimization Using Aerosil®-200 and Avicel® Ph-101 With Factorial Design. Int Res J Pharm. 2020;11(2):25–31. https://doi.org/10.7897/2230-8407.110215

. Qader AB, Abbas Hussein A. Novel Oral Solid Self-Nanoemulsifying Drug Delivery System (S-Snedds) of Rosuvastatin Calcium: Formulation, Characterization, Bioavailability and Pharmacokinetic Study. Syst Rev Pharm. 2021;12(1):137–48.

. Priani SE, Somantri SY, Aryani R. Formulasi dan Karakterisasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Mengandung Minyak Jintan Hitam dan Minyak Zaitun. J Sains Farm Klin. 2020;7(1):31. https://doi.org/10.25077/jsfk.7.1.31-38.2020

. Saryanti D, Setiawan I, Tinggi S, Kesehatan I. Optimization of Selfnanoemulsifying Drug Delivery System (SNEDDS) Formulation of Ethil Acetate Fraction Soursop Leaf as Antioxidant. Indones J Glob Health Res. 2019;4(3):559–66. https://doi.org/10.37287/ijghr.v2i4.250

. Fitria A, Hanifah S, Chabib L, Uno AM, Munawwarah H, Atsil N, et al. Design and Characterization of Propolis Extract Loaded Self-Nanoemulsifying Drug Delivery System as Immunostimulant. Saudi Pharm J. 2021;29(6):625–34. https://doi.org/10.1016/j.jsps.2021.04.024

. Syukri Y, Kholidah Z, Chabib L. Formulasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi , Cremophor RH 40 dan PEG 400. J Sains Farm Dan Klin. 2019;6(3):265–73.

. Alwadei M, Kazi M, Alanazi FK. Novel Oral Dosage Regimen Based on Self-Nanoemulsifying Drug Delivery Systems for Codelivery of Phytochemicals – Curcumin and Thymoquinone. Saudi Pharm J. 2019;27(6):866–76. https://doi.org/10.1016/j.jsps.2019.05.008

. Devireddy SK, Jonnalagadda LP. A Literature Review on Self Nanoemulsifying Drug Delivery System (SNEDDS). Int J Pharm Sci Rev Res. 2021;70(1):85–94. https://doi.org/10.47583/ijpsrr.2021.v70i01.011

. Dokania S, Joshi AK. Self-Microemulsifying Drug Delivery System (SMEDDS)-Challenges and Road Ahead. Drug Deliv. 2015;22(6):675–90. https://doi.org/10.3109/10717544.2014.896058

. Maruti TS, Bobe K, Potnis DrV, Dhamane S, Suresh PV. A Review - Self Nanoemulsifying Drug Delivery System (SNEDDS). World J Pharm Res. 2014;3(3):5041–8. https://doi.org/10.20959/wjpr20207-17923

. Singh B, Bandopadhyay S, Kapil R, Singh R, Katare OP. Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization, and Applications. Crit Rev Ther Drug Carrier Syst. 2009;26(5):427–521. https://doi.org/10.1615/critrevtherdrugcarriersyst.v26.i5.10

. Pouton CW. Lipid Formulations for Oral Administration of Drugs: Non-Emulsifying, Self-Emulsifying and “Self-Microemulsifying†Drug Delivery Systems. Eur J Pharm Sci. 2000;11(SUPPL. 2):93–8. https://doi.org/10.1016/S0928-0987(00)00167-6

. Kuruvila FS, Mathew F, Kuppuswamy S. Solid Self Nanoemulsifying Drug Delivery System (SNEDDS ) Devolopment , Applications and Future Perspective : A Review. Indo Am J Pharm Sci. 2017;4(03):651–69.

. Anupam V, Rajesh A, Anil G. Self-Nanoemulsifying Drug Delivery System: An Updated Review. Trop J Pharm Life Sci. 2022;9(2):11–20.

. Jasmina H, Džana O, Alisa E, Edina V, Ognjenka R. Preparation of Nanoemulsions By High-Energy and Low- Energy Emulsification Methods. Int Fed Med Biol Eng Proc. 2017;62:317–22. https://doi.org/10.1007/978-981-10-4166-2

. Sulkhan AAR, Artanti AN, Ermawati DE, Prihapsara F. Optimization of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Annona muricata L. Leaves Chloroform Extract Using VCO (Virgin Coconut Oil) As an Oil Phase. IOP Conf Ser Mater Sci Eng. 2019;578(1). https://doi.org/10.1088/1757-899X/578/1/012046

. Artanti AN, Prihapsara F, Rohmani S. Cytotoxicity Effect of Self-Nanoemulsifying Drug Delivery System from Chloroform Extract of Bay Leaf (Syzygium Polyanthum (Wight ) Walp.) with Oleic Acid as a Carrier. Indones J Cancer Chemoprevention. 2022;13(2):94–103.

. Nugroho BH, Citrariana S, Sari IN, Oktari RN, Munawwarah. Formulasi dan evaluasi SNEDDS (Self Nanoemulsifying Drug Delivery System) ekstrak daun pepaya (Carica papaya L.) sebagai analgesik. J Ilm Farm. 2017;13(2):77–85. https://doi.org/10.20885/jif.vol13.iss2.art5

. Hastuti ED, Sukarno. Formulasi Sediaan Self Nanoemulsifying Drug Delivery System (SNEDDS) Ekstrak Etil Asetat Buah Parijoto (Medinilla speciosa Blume ) Serta Uji Stabilitas Fisik. J Farm Cendekia. 2020;4(2):131–7.

. Hayati F, Chabib L, Sekarraras FD, Faizah WS. Antihyperglycemic Activity of Centella asiatica (L.) Urb. Leaf Ethanol Extract SNEDDS in Zebrafish (Danio rerio). Open Chem. 2021;19(1):184–8. https://doi.org/10.1515/chem-2021-0200

. Fitriani H, Fitria A, Miladiyah I, Syukri Y. Pengembangan Self-Nano Emulsifying System (SNES) Ekstrak Temulawak (Curcuma xanthorrhiza): Formulasi, Karakterisasi, dan Stabilitas. J Sains Farm Klin. 2021;8(3):332. https://doi.org/10.25077/jsfk.8.3.332-339.2021

. Hayati F, Chabib L, Darma DD. Antihyperglycemia Activity of Self-Nanoemulsifying Drug-Delivery Systems (SNEDDS) of Ipomoea reptans, Poir Leaf Ethanolic Extract in Zebrafish (Danio rerio). AIP Conf Proc. 2018;2026(2018). https://doi.org/10.1063/1.5064986

. Erliyana M, Widyaningsih W, Wumu DA, Wulansari WF. Formulation of Self-Nano emulsifying Drug Delivery System (SNEDDS) Red Ginger Extract (Zingiber Officinale var. rubrum). Media Farm J Ilmu Farm. 2022;19(2):133. https://doi.org/10.12928/mf.v19i2.21655

. Suryani, Zubaydah WOS, Sahumena MH, Adawia S, Wahyuni R, Adjeng ANT, et al. Preparation and Characterization of Self-Nanoemulsifying Drug Delivery System (SNEDDS) from Moringa oleifera L.and Cassia alata L. Leaves Extracts. AIP Conf Proc. 2019;2199(2019). https://doi.org/10.1063/1.5141325

. Gunasekaran T, Haile T, Nigusse T, Dhanaraju MD. Nanotechnology: An Effective Tool for Enhancing Bioavailability and Bioactivity of Phytomedicine. Asian Pac J Trop Biomed. 2014;4(Suppl 1):S1–7. https://doi.org/10.12980/APJTB.4.2014C980

. Ahmed HM, Nabavi S, Behzad S. Herbal Drugs and Natural Products in The Light of Nanotechnology and Nanomedicine for Developing Drug Formulations. Mini-Rev Med Chem. 2020;21(3):302–13. https://doi.org/10.2174/1389557520666200916143240

. Kesarwani K, Gupta R. Bioavailability Enhancers of Herbal Origin: An Overview. Asian Pac J Trop Biomed. 2013;3(4):253–66. https://doi.org/10.1016/S2221-1691(13)60060-X

. Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Self-Nanoemulsifying Drug Delivery System (SNEDDS) of The Poorly Water-Soluble Grapefruit Flavonoid Naringenin: Design, Characterization, In Vitro and In Vivo Evaluation. Drug Deliv. 2015;22(4):552–61. https://doi.org/10.3109/10717544.2013.878003

. Kassem AA, Mohsen AM, Ahmed RS, Essam TM. Self-Nanoemulsifying Drug Delivery System (SNEDDS) with Enhanced Solubilization of Nystatin for Treatment of Oral Candidiasis: Design, Optimization, In Vitro and In Vivo Evaluation. J Mol Liq. 2016;218:219–32. https://doi.org/10.1016/j.molliq.2016.02.081

. Vanani RN, Moezi L, Heli H. In Vivo Evaluation of A Self-Nanoemulsifying Drug Delivery System for Curcumin. Biomed Pharmacother. 2017;88:715–20. https://doi.org/10.1016/j.biopha.2017.01.102

. Nugroho BH, Syafaudin MR, Fauzi LR, Anggraini E, Ritonga HO. Snedds (Self-nanoemulsifying Drug Delivery System) Formulation of Sarang Semut Extract on Cervical Cancer Cells (HeLa) with MTT Assay Method. J Phys Conf Ser. 2020;1445(1). https://doi.org/10.1088/1742-6596/1445/1/012020

. Pratiwi L. Novel Antimicrobial Activities of Self-Nanoemulsifying Drug Delivery System Ethyl Acetate Fraction from Garcinia mangostana L. peels Against Staphylococcus epidermidis: Design, Optimization, and In Vitro Studies. J Appl Pharm Sci. 2021;11(3):162–71. https://doi.org/10.7324/JAPS.2021.110313

. Kalantari A, Kósa D, Nemes D, Ujhelyi Z, Fehér P, Vecsernyés M, et al. Self-Nanoemulsifying Drug Delivery Systems Containing Plantago lanceolata—An Assessment of Their Antioxidant and Antiinflammatory Effects. Molecules. 2017;22(10). https://doi.org/10.3390/molecules22101773

. Kassem AA, Abd El-Alim SH, Salman AM, Mohammed MA, Hassan NS, El-Gengaihi SE. Improved Hepatoprotective Activity of Beta vulgaris L. Leaf Extract Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS): In Vitro and In Vivo Evaluation. Drug Dev Ind Pharm. 2020;46(10):1589–603. https://doi.org/10.1080/03639045.2020.1811303

. Anindhita MA, Oktaviani N. Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Ekstak Daun Pepaya (Carica papaya L.) dengan Virgin Coconut Oil (VCO) sebagai Minyak Pembawa. Pena Med J Kesehat. 2016;6(2):103–11.

. Fitria A, Hanifah S, Chabib L, Uno AM, Munawwarah H, Atsil N, et al. Design and characterization of propolis extract loaded self-nano emulsifying drug delivery system as immunostimulant. Saudi Pharm J. 2021;29(6):625–34. https://doi.org/10.1016/j.jsps.2021.04.024