Analgesic Activity of Papaya Leaf Extract (Carica papaya L.) on Male Mice induced by Acetic Acid 1%
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Keywords:
analgesic activity, carica papaya leaves, writhing movements.
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Abstract
Analgesic activity of extract of papaya leaves (Carica papaya L.) to male mice has been evaluated. Twenty five of mice (20-30 g, 2-3 months old) were divided randomly into five groups. The first group was given sodium CMC as negative control, the second until fourth groups received ethanolic extract of Carica papaya leaves in the doses of 100, 300, and 600 mg/kgBW, respectively and the fifth group was given paracetamol 65 mg/kg BW. All interventions were administered as single dose by oral route on given day. Acetic acid 1% (w/v) was used as the pain inductor. Analgesic activity was measured by counting the percentage of writhing movements as a measure of the analgesic effect produced by each intervention. Data were analyzed with one way ANOVA to compare analgesic activity between treatment groups. The results showed that the analgesic effect of the extract on the doses of 100, 300, and 600 mg/kg BW was significantly different with control group (P<0.05). It may be concluded that the analgesic effect of an ethanolic extract of Carica papaya leaves in mice was of similar potency as paracetamol.
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Afrianti, R., Yenti, R., & Meustika, D. (2015). Analgesic Activity of Papaya Leaf Extract (Carica papaya L.) on Male Mice induced by Acetic Acid 1%. Jurnal Sains Farmasi & Klinis, 1(1), 54–60. https://doi.org/10.29208/jsfk.2014.1.1.12
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Research Articles
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Mikaili, P., Sharifi, M., Sarahroodi, S., & Shayegh, J. (2012). Pharmacological review of medicinal trees spontaneous in Iran: A historical and modern study. Advances in Environmental Biology, 6(1), 165-175.
Winarsi, H. (2007). Antioksidan alami dan radikal bebas. Yogyakarta: Kanisius.
Mutschler, Ernst. (1991). Dinamika obat: Buku ajar farmakologi dan toksikologi (edisi 5). Bandung: ITB.
Somchit, M. N., Shukriyah, M. H. N., Bustamam, A. A., & Zuraini, A. (2005). Anti-pyretic and analgesic activity of Zingiber zerumbet. International Journal of Pharmacology, 1(3), 277-280.
Turner, R. A. (1965). Screening methods in pharmacology. New York: Academic Press.
Astuti, N. & Pudjiastuti. (1996). Penelitian khasiat biji ketumbar (Coriandrium sativum L.) sebagai analgesik pada mencit. Prosiding Simposum Penelitian Bahan Obat Alami VIII. Bogor; Badan Penelitian Tanaman Rempah dan Obat (BALITTRO) dengan Perhimpunan Penelitian Bahan Obat Alami (PERHIPBA).
Thompson, E. B. (1985). Drug bioscreening fundamental of drug evaluation technique in pharmacology. New York Publishing Co, Inc.
Sirait, M. D., Hargono, D., Wattimena, J. R., Husin, M., Sumadilaga, R. S., & Santoso, S. O. (1993). Pedoman pengujian pengembangan fitofarmaka, penapisan farmakologi pengujian fitokimia dan pengujian klinik pengembangan dan pemanfaatan obat bahan alam. Jakarta: Yayasan Pengembangan Obat Bahan Alam Phytomedica.
Amri, E., & Mamboya, F. (2012). Papain, a plant enzyme of biological importance: A review. American Journal of Biochemistry & Biotechnology, 8(2), 99-104.
Namita, P., & Mukesh, R. (2012). Medicinal plants used as antimicrobial agents: A review. International Research Journal of Pharmacy, 3(1), 31-40.