Formulation of Mucoadhesive Ketoprofen Granule Using Chitosan Polymer
Article Sidebar
Keywords:
mucoadhesive granules, ketoprofen, chitosan, in vitro dissolution test, in vitro mucoadhesive.
Main Article Content
Abstract
The aim of this research was to formulate of mucoadhesive ketoprofen granules using chitosan polymer. Ketoprofen granules were prepared by wet granulation method with several concentrations of chitosan polymer 0%, 10%, 20%, and 30% (w/v). Granules were evaluated physically and chemically. In vitro dissolution test was carried out for 6 hours using a basket method in buffer phosphate medium pH 7.4. General evaluation of granules showed the yield was relatively good. In vitro mucoadhesive test exhibited that mucoadhesive ketoprofen granules using chitosan polymer could provide mucoadhesive properties to stomach and intestinal of rabbits. The statistics tests for dissolution efficiency with one ways ANOVA (SPSS 17) showed a significant different among F0, F1, F2 and F3 (P0.05). All the formulas followed Langenbucher kinetic release model.
Article Details
How to Cite
Umar, S., Ningsih, W., & Meliana, M. (2015). Formulation of Mucoadhesive Ketoprofen Granule Using Chitosan Polymer. Jurnal Sains Farmasi & Klinis, 1(1), 48–53. https://doi.org/10.29208/jsfk.2014.1.1.11
Issue
Section
Research Articles
The authors retain the copyright and grant the journal the right of first publication simultaneously under the Creative Commons Attribution License. This license allows others to share the work with proper acknowledgment of authorship and initial publication in this journal. Authors are permitted and encouraged to deposit their articles in institutional repositories, on their personal websites, or in other online repositories after the article has been published in JSFK.
References
Yamada, T., Onishi, H., & Machida, Y., (2001). In Vitro and In Vivo Evaluation of Sustained Release Chitosan-Coated Ketoprofen Microparticles. Yakugaku Zasshi, 121, 239-245.
Indrawati, T., Goeswin, A., Elin, Y., & Yeyet, C., (2005). Uji Daya Lekat Mukoadhesif Secara In Vitro Beberapa Eksipien Polimer Tunggal dan Kombinasinya pada Lambung dan Usus Tikus. Jurnal Matematika dan Sains 10, 45-51.
Ahuja, A., Khar. R. K., & Ali, J., (1997). Muchoadhesive Drug Delivery System. Drug Development and Industrial. Pharmacy, 23, 489-515.
Lenearts, V., Couvreur, P, Grislain, L., & Maincent, P., (1990). Bioadhesive Drug Delivery Systems. CRC Press: Boca Raton.
Sutriyo, Joshita, D., & Indah, R. (2005). Perbandingan Pelepasan Propanolol Hidroklorida Dari Matriks Kitosan, Etil Selulosa dan Hidroksipropil Metil Selulosa. Majalah Ilmu Kefarmasian 2, 145-153.
Shaji, J., Jain, V., & Lodha, S., (2010). Chitosan: A novel pharmaceutical excipient. International Journal of Pharmaceutical and Applied Sciences 1, 1.
Dutta, P. K., Dutta, J., & Triphati, V. S., (2004). Chitin and Chitosan: chemistry, properties and applications. Journal of Scientific and Industrial Research, 63, 20-31.
Departemen Kesehatan RI. (1995). Farmakope Indonesia Edisi IV. Departemen Kesehatan Republik Indonesia: Jakarta.
Nafsiah. (2009). Formulasi Sediaan Lepas Lambat Tablet Teofilin Dengan Matriks Natrium Carboxymetil Cellulose Dan Avicel pH 102 Dengan Metode Granulasi Basah. Fakultas Farmasi Universitas Muhammadiyah Surakarta: Surakarta.
Siregar, C. J. P. (2010). Teknologi Farmasi Sediaan Tablet. EGC: Jakarta.
Deshmuskh, V. N., Jadhav, J. K., & Sakarkar, D. M. (2009). Formulation and In Vitro Evaluation of Theophylline Anhydrous Bioadhesive Tablets. Departement of Pharmaceutics, S N Institude of Pharmacy: India.
Agoes, G. (2008). Sistem Penghantaran Obat Pelepasan Terkendali. Penerbit ITB: Bandung.
Indrawati, T., Goeswin, A., Elin, Y., & Yeyet, C., (2005). Uji Daya Lekat Mukoadhesif Secara In Vitro Beberapa Eksipien Polimer Tunggal dan Kombinasinya pada Lambung dan Usus Tikus. Jurnal Matematika dan Sains 10, 45-51.
Ahuja, A., Khar. R. K., & Ali, J., (1997). Muchoadhesive Drug Delivery System. Drug Development and Industrial. Pharmacy, 23, 489-515.
Lenearts, V., Couvreur, P, Grislain, L., & Maincent, P., (1990). Bioadhesive Drug Delivery Systems. CRC Press: Boca Raton.
Sutriyo, Joshita, D., & Indah, R. (2005). Perbandingan Pelepasan Propanolol Hidroklorida Dari Matriks Kitosan, Etil Selulosa dan Hidroksipropil Metil Selulosa. Majalah Ilmu Kefarmasian 2, 145-153.
Shaji, J., Jain, V., & Lodha, S., (2010). Chitosan: A novel pharmaceutical excipient. International Journal of Pharmaceutical and Applied Sciences 1, 1.
Dutta, P. K., Dutta, J., & Triphati, V. S., (2004). Chitin and Chitosan: chemistry, properties and applications. Journal of Scientific and Industrial Research, 63, 20-31.
Departemen Kesehatan RI. (1995). Farmakope Indonesia Edisi IV. Departemen Kesehatan Republik Indonesia: Jakarta.
Nafsiah. (2009). Formulasi Sediaan Lepas Lambat Tablet Teofilin Dengan Matriks Natrium Carboxymetil Cellulose Dan Avicel pH 102 Dengan Metode Granulasi Basah. Fakultas Farmasi Universitas Muhammadiyah Surakarta: Surakarta.
Siregar, C. J. P. (2010). Teknologi Farmasi Sediaan Tablet. EGC: Jakarta.
Deshmuskh, V. N., Jadhav, J. K., & Sakarkar, D. M. (2009). Formulation and In Vitro Evaluation of Theophylline Anhydrous Bioadhesive Tablets. Departement of Pharmaceutics, S N Institude of Pharmacy: India.
Agoes, G. (2008). Sistem Penghantaran Obat Pelepasan Terkendali. Penerbit ITB: Bandung.