Penambatan Molekul dan Dinamika Molekul beberapa Fitokimia dari Acalypha Indica L. sebagai Inhibitor Matriks Metalloproteinase9
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. NHS. Chemotherapy - NHS [Internet]. 2020 [cited 2022 Feb 13]. Available from: https://www.nhs.uk/conditions/chemotherapy/#:~:text=Chemotherapy is a cancer treatment,and spreading in the body
. Löffek S, Schilling O, Franzke C-WW. Biological role of matrix metalloproteinases: a critical balance. Eur Respir J. 2011;38(1):191–208. https://doi.org/10.1183/09031936.00146510
. Dufour A, Overall CM. Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends Pharmacol Sci. 2013;34(4):233–42. https://doi.org/10.1016/J.TIPS.2013.02.004
. Accorsi-Mendonça T, Paiva KB da S, Zambuzzi WF, Cestari TM, Lara VS, Sogayar MC, et al. Expression of matrix metalloproteinases-2 and-9 and RECK during alveolar bone regeneration in rat. J Mol Histol. 2008;39(2):201–8. https://doi.org/10.1007/S10735-007-9152-Z
. Sakthi SS, Geetha M, Saranraj P. PHARMACOLOGICAL SCREENING OF Datura metel AND Acalypha indica FOR ITS ANTIFUNGAL ACTIVITY AGAINST PATHOGENIC FUNGI. Int J Pharm Sci Heal care. 2011;1(2):15–30.
. Kalimuthu S, Rajesh P, Kannan VR, Balamurugan B, Chandrasekar TM. Antiulcer activity of Methanolic extract of Acalypha indica Linn. (Euphorbiaceae) by Pylorous Ligture and Swim Stress Induced Ulceration. J Pharm Res. 2010;3(11):2779–83.
. Sundararaman P, Djerassi C. A convenient synthesis of progesterone from stigmasterol. J Org Chem. 2002;42(22):3633–4. https://doi.org/10.1021/JO00442A044
. Gupta S, Bandopadhyay A. Overcoming seed dormancy of Acalypha indicaL.(Euphorbiaceae): An important medicinal plant. Indian J Plant Sci. 2013;2(1):72–9.
. Syahiran N, Mohamed R, Idayu I, Zahidin NS, Saidin S, Zulkifli RM, et al. review of Acalypha indica L.(Euphorbiaceae) as traditional medicinal plant and its therapeutic potential. J Ethnopharmacol. 2017;207:146–73. https://doi.org/10.1016/J.JEP.2017.06.019
. Chen X, Ung CY, Chen Y. Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients? Nat Prod Rep. 2003;20(4):432–44. https://doi.org/10.1039/B303745B
. Bitencourt-Ferreira G, Pintro VO, de Azevedo WF. Docking with AutoDock4. In: Methods in Molecular Biology. Humana, New York, NY; 2019. p. 125–48. https://doi.org/10.1007/978-1-4939-9752-7_9
. NCBI Nc. PubChem Compound Database. Natl Cent Biotechnol Inf. 2018;
. Kohnke B, Kutzner C, Grubmüller H, Grubmüller H. A GPU-accelerated Fast Multipole Method for GROMACS: performance and accuracy. J Chem Theory Comput. 2020;16(11):6938–49. https://doi.org/10.1021/ACS.JCTC.0C00744
. Bernardi A, Faller R, Reith D, Kirschner KN. ACPYPE update for nonuniform 1–4 scale factors: Conversion of the GLYCAM06 force field from AMBER to GROMACS. SoftwareX. 2019;10:100241. https://doi.org/10.1016/J.SOFTX.2019.100241
. Asnawi A, Aman LO, Nursamsiar, Yuliantini A, Febrina E. MOLECULAR DOCKING AND MOLECULAR DYNAMIC STUDIES: SCREENING PHYTOCHEMICALS OF Acalypha indica AGAINST BRAF KINASE RECEPTORS FOR POTENTIAL USE IN MELANOCYTIC TUMOURS. Rasayan J Chem. 2022;15(2):1352–61. https://doi.org/10.31788/RJC.2022.1526769
. Valdés-Tresanco MES, Valdés-Tresanco MES, Valiente PA, Moreno E. Gmx_MMPBSA: A New Tool to Perform End-State Free Energy Calculations with GROMACS. J Chem Theory Comput. 2021;17(10):6281–91. https://doi.org/10.1021/acs.jctc.1c00645
. Ischak NI, Ode LA, Hasan H, Kilo A La, Asnawi A. In silico screening of Andrographis paniculata secondary metabolites as anti-diabetes mellitus through PDE9 inhibition. Res Pharm Sci. 2023;18(1):100. https://doi.org/10.4103/1735-5362.363619
. Mukherjee S, Balius TE, Rizzo RC. Docking Validation Resources: Protein Family and Ligand Flexibility Experiments. J Chem Inf Model. 2010;50(11):1986–2000. https://doi.org/10.1021/CI1001982
. Genheden S, Ryde U. The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Expert Opin Drug Discov. 2015;10(5):449–61. https://doi.org/10.1517/17460441.2015.1032936
. Tuccinardi T. What is the current value of MM/PBSA and MM/GBSA methods in drug discovery? [Internet]. Vol. 16, Expert Opinion on Drug Discovery. Taylor & Francis; 2021. p. 1233–7. https://doi.org/10.1080/17460441.2021.1942836
DOI: https://doi.org/10.25077/jsfk.10.1.62-70.2023
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