Perbandingan Efikasi Karbamazepin, Gabapentin Dan Amitriptilin Terhadap Nyeri Pada Penderita Polineuropati Diabetik

Ken Wirastuti, Amalia Nirma Sari, Dwi Arditi Dewi, Widya Ayu Setyaningrum, Atina Hussaana
10.25077/jsfk.10.2.205-210.2023

Abstrak


Perbedaan mekanisme kerja obat Karbamazepin, Gabapentin, dan Amitriptilin dapat mempengaruhi efektivitasnya dalam mengurangi nyeri pada polineuropati diabetik. Untuk membantu pemilihan terapi yang paling tepat untuk mengelola nyeri tersebut, maka perlu dilakukan penelitian ini.  Penelitian dilakukan secara eksperimental dengan  rancangan pretest-posttest group design.  Pengukuran respon nyeri menggunakan Visual Analogue Scale (VAS) dilakukan sebelum dan sesudah perlakuan dengan Gabapentin, Carbamazepine, dan Amitriptyline. Perbedaan respon nyeri sebelum-sesudah dan antar perlakuan dianalisis dengan uji Mann-Whitney dan uji T-independent. Hasil penelitian menunjukkan bahwa ketiga obat tersebut  efektif dalam mengurangi respon nyeri pada pasien polineuropati diabetik, namun Amitriptyline lebih efektif pada pasien nyeri ringan sampai sedang dibandingkan dengan Gabapentin. Temuan ini memberikan informasi berharga bagi penyedia layanan kesehatan dalam memilih pengobatan yang paling efektif untuk pasien dengan nyeri polineuropati diabetik.


Kata Kunci


polineuropati diabetik; gabapentin; karbamazepin; amitriptilin; visual analogue scale.

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Referensi


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DOI: https://doi.org/10.25077/jsfk.10.2.205-210.2023

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