Penggunaan D-Optimal Mixture Design untuk Optimasi dan Formulasi Self-Nano Emulsifying Drug Delivery System (SNEEDS) Asam Mefenamat

Yandi Syukri, Bambang Hernawan Nugroho, Istanti Istanti

Abstrak


Penelitian ini bertujuan untuk melakukan optimasi formulasi asam mefenamat yang sukar larut dalam air dalam bentuk sediaan Self-Nano Emulsifying Drug Delivery System (SNEDDS) menggunakan D-optimal mixture design. Skrining awal dilakukan untuk menentukan fase minyak, surfaktan dan ko-surfaktan yang akan digunakan untuk pembuatan diagram fase terner. D-optimal mixture design digunakan untuk mengoptimasi SNEDDS asam mefenamat dengan memilih komposisi SNEDDS sebagai faktor independent dan karakterisasi SNEDDS sebagai respons. Karakterisasi SNEDDS pada formula optimal meliputi transmitan, ukuran partikel, polidispersity index (PDI) dan zeta potensial. Asam oleat, Tween 80, dan polietilenglikol (PEG) 400 merupakan fase minyak, surfaktan, dan ko-surfaktan yang terpilih karena memiliki kemampuan paling tinggi dalam melarutkan asam mefenamat. Hasil optimasi menunjukkan bahwa formula optimal diperoleh pada komposisi 10% asam oleat, 80% Tween 80 dan 10% PEG 400. SNEDDS asam mefenamat tersebut menghasilkan nanoemulsi dengan transmitan 88,5%, ukuran partikel 190,03 ± 1,18 nm, PDI 0,469 ± 0,03, dan zeta potensial -44,1 ± 1,69 mV. Studi ini menyimpulkan bahwa D-optimal mixture design dapat digunakan untuk mengoptimasi dan formulasi SNEDDS asam mefenamat yang sukar larut dalam air.


Kata Kunci


asam mefenamat; SNEDDS; D-optimal mixture design; asam oleat

Teks Lengkap:

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Referensi


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DOI: https://doi.org/10.25077/jsfk.7.3.180-187.2020

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