Formulasi dan Karakterisasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Mengandung Minyak Jintan Hitam dan Minyak Zaitun

Sani Ega Priani, Sri Yulianingsih Somantri, Ratih Aryani

Abstrak


Self Nanoemulsifying Drug Delivery System (SNEDDS) diketahui mampu meningkatkan absorbsi oral dari senyawa senyawa hidrofob. Penelitian ini bertujuan untuk memformulasi dan mengkarakterisasi sediaan SNEDDS mengandung kombinasi minyak jintan hitam dan minyak zaitun. Penelitian diawali dengan analisis kandungan senyawa pada minyak jintan hitam dan minyak zaitun dengan metode Gas Chromatography Mass Spectrophotometry (GC-MS). Optimasi formula dilakukan dengan variasi konsentrasi minyak, surfaktan, dan kosurfaktan. Sediaan SNEDDS selanjutnya dikarakterisasi dengan pengujian persen transmitan, dispersibilitas, robustness, termodinamika (sentrifugasi, heating cooling cycle, freeze thaw cycle), penentuan ukuran serta morfologi globul nanoemulsi. Formula SNEDDS terbaik mengandung surfaktan cremophor RH 40 dan kosurfaktan PEG 400 (3:2) dengan perbandingan fase minyak dan campuran surfaktan kosurfaktan 1:7. Sediaan tersebut memenuhi persyaratan persen transmitan (97,27 ± 0,06%), uji dispersibilitas (grade A), stabil pada pengujian robustness dan termodinamika. Sediaan SNEDDS mampu membentuk nanoemulsi secara spontan dengan rata-rata ukuran globul 99 nm dengan globul berbentuk sferis. Studi ini menyimpulkan bahwa sediaan SNEDDS yang mengandung minyak jintan hitam dan minyak zaitun pada formula optimum memiliki karakteristik fisik yang baik.


Kata Kunci


SNEDDS; minyak jintan hitam; minyak zaitun,

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Referensi


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DOI: https://doi.org/10.25077/jsfk.7.1.31-38.2020

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