Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) Terhadap Fungsi Ginjal Tikus

Yori Yuliandra, Armenia Armenia, Annisa Nur Salasa, Friardi Ismed

Abstrak


Pengujian toksisitas subkronis ekstrak etanol tali putri (Cassytha filiformis L.) terhadap fungsi ginjal tikus telah dilakukan. Sebanyak 16 ekor tikus jantan berusia 2-3 bulan dengan berat badan ±250 gram digunakan sebagai hewan uji. Hewan dibagi menjadi 4 kelompok, yaitu 1 kelompok kontrol dan 3 kelompok perlakuan yang diberi ekstrak etanol tali putri dengan dosis 1,25; 2,5; dan 5 mg/kg sekali sehari secara intraperitoneal selama 14 hari. Data bersihan kreatinin, persentase fungsi ginjal, dan rasio organ ginjal dianalisis dengan ANOVA dua arah dan dilanjutkan dengan uji Duncan’s post hoc test. Hasil penelitian menunjukkan bahwa bersihan kreatinin dan persentase fungsi ginjal rata-rata tikus mengalami penurunan secara bermakna selama perlakuan (p<0,05). Rasio berat organ ginjal kelompok ekstrak, terutama pada dosis besar mengalami peningkatan dengan sangat bermakna (p<0,01) dibandingkan dengan kelompok kontrol. Ini menunjukkan bahwa ekstrak etanol tali putri dengan dosis 1,25-5 mg/kg dapat menyebabkan penurunan fungsi ginjal, tetapi masih relatif aman bila digunakan selama 14 hari.


Kata Kunci


cassytha filiformis; tali putri; toksisitas subkronis; fungsi ginjal; bersihan kreatinin

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Referensi


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DOI: https://doi.org/10.29208/jsfk.2015.2.1.47

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