Formulasi Emulgel Ekstrak Bawang Putih (Allium sativum L.)

Widyasari Putranti, Akmal Maulana, Siti Fatmawati Fatimah

Abstrak


Garlic have an activity as antifungal. Garlic extract need to be non spesific standarized to get consistent quality. Emulgel have hydrophobic or hidrophilic active substances because emulgel is a combination of emulsion and gel. This study aims to obtain the garlic extract emulgel formula which has good quality and good physical properties.The garlic extraction method maceration method with ethanol 96% as a solvent (1:7.5). Non spesific parameter of extract standardization were powder lost on drying, water content, ash content, acid-insoluble ash content, mass of extract spesification. Extract were standardized and then formulated in emulgel dosage form with 25% concentration of extract, then emulgel evaluated for physical properties include organoleptic test, homogeneity, pH, temperature stability, spreadability, stickiness, type of emulsion, and viscosity. The results showed rendemen of extract (8.90 ± 0.12)%,  lost on drying (6.85 ± 0.11)%, water content of extract (4.16 ± 1.4)%, ash content of powder (3.24 ± 0.02)% and extract (1.14  ±  0.03)%, acid-insoluble ash content powder (0.96 ± 0.02)% and extract (0.61 ±  0.07)%, the mass of extract spesification 1.028, and for the physical properties test of emulgel preparations obtained homogeneous emulgel, semisolid form, light brown color, smell of extract garlic, stable at 5ºC and 25ºC for 24 hours, pH 7, spreadability (2.49±0.12) g.cm.s-1, stickiness (61.99±5.81)seconds, type of emulsion o/w, viscosity(2.63±0.22) Pa.s. Based on the study was obtained garlic extract that fulfill the requirements of non spesific parameter standardization from Farmakope Herbal Indonesia and emulgel formulation of garlic extract has good physical properties.


Kata Kunci


Garlic extract, non-specific parameter of standardization, emulgel

Teks Lengkap:

PDF

Referensi


Aly, M.M., Al-Aidroos, B.A. & Alfassi, F.A. 2011, Production of non polyenic antifungal agent from Streptomyces sp BM54, isolated from marine shripms. Crown Journal of Medicine, Vol. 1 No.1 Hal. 01-08

Amichai, B., & Grunwald, M.H. 1998. Adverse drug reactions of the new oral antifungal agents–terbinafine, fluconazole, and itraconazole. International Journal of Dermatology, No. 37 Hal. 410-415

Anam, Syariful., M. Yusran., A. Trisakti., N. Ibrahim., Ahmad K., Ramadanil., & M.S. Zubair. 2013, Standarisasi Ekstrak Etil Asetat Kayu Sanrego (Lunasia amara Blanco). Online Jurnal of Natural Science, Vol. 2 No. 3 Hal. 1-8

Ankri, Serge & David Mirelman. 1999, Antimicrobial properties of allicin from garlic. Elsevier : Microbes and Infection, No. 2 Hal. 125−129

Aulton, M.E., & Collet, D.M. 1990, Pharmaceutical Practice. United States of America: Churchill Livingstone Inc, p: 115.

Ansel, H. C. (ed). 2005. Pengantar Bentuk Sediaan Farmasi. 4th ed. Jakarta: Universitas Indonesia Press, pp: 605-619.

Anwar, E., Ramadon, D., & Harmita. 2014, Formulation and evaluation of gel and emulgel of chili extract (Capsicum frutescens L.) as topical dosage forms. International Journal of Pharmacy and Pharmaceutical Sciences. Vol. 6 No. 3 Hal. 13-15

Azizah, B., Salamah, N. 2013, Standarisasi Parameter Non Spesifik Dan Perbandingan Kadar Kurkumin Ekstrak Etanol Dan Ekstrak Terpurifikasi Rimpang Kunyit. Jurnal Ilmiah Kefarmasian, Vol. 3 No. 1 Hal. 21-30

Badan Pusat Statistik, 2008, Statistik Kesejahteraan Rakyat (Welfare Statistics). Jakarta: 72–80.

BPOM. 1985, Cara Pembuatan Simplisia. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan.

BPOM. 2000, Parameter Standar Umum Ekstrak Tumbuhan Obat. 1st ed. Jakarta: Departemen Kesehatan Republik Indonesia.

BPOM. 2010, Acuan Sediaan Herbal. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia. Direktorat Obat Asli Indonesia Deputi Bidang Pengawasan Obat Tradisional Kosmetik dan Produk Komplemen

Depkes RI. 1978, Materia Medika Indonesia. 2nd ed. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan

Depkes RI. 1979, Farmakope Indonesia, 3rd ed, Jakarta: Departemen Kesehatan Republik Indonesia.

Depkes RI. 1994, Keputusan Menteri Kesehatan Republik Indonesia Nomor 661/MENKES/SK/VII/1994 tentang Persyaratan Obat Tradisional. Jakarta, Departemen Kesehatan Republik Indonesia

Depkes RI. 2008, Farmakope Herbal Indonesia. 1st ed. Jakarta: Departemen Kesehatan Republik Indonesia.

Deresse, D. 2010, Antibacterial Effect of Garlic (Allium sativum) on Staphylococcus aureus: An in vitro Study. Asian Journal of Medical Sciences, Vol. 2 No. 2 Hal. 62-65

Dewangga, L.A. 2013, Aktivitas Antibakteri Ekstrak Etanol Dan Fraksi Nonpolar Ekstrak Etanol Bawang Putih (Allium sativum L.) Terhadap Bakteri Streptococcus mutans dan Pseudomonas aeruginosa serta Bioautografi. Skripsi. Surakarta: Universitas Muhammadiyah Surakarta.

Dusica, P., Vesna, D., Ljubisa, B., & Mihajlo, Z. 2011, Allicin and related compounds: biosynthesis and pharmacological activity. Physics, Chemistry and Technology, Vol. 9 No. 1 Hal. 9-20

Fujisawa, H., Suma, K., Origuchi, K., Kumagai, H., Seki, T., & Ariga, T. 2008. Biological and Chemical Stability of Garlic - Derived Allicin. Journal Agricultural And Foof Chemistry, No. 56 Hal. 4229 – 4235

Gandjar, I.G., dan Rohman, A., 2013, Kimia Farmasi Analisis, Pustaka Pelajar, Yogyakarta

Guntarti, A., Sholehah, K., Irna, N., & Fistianingrum, W. 2015, Penentuan Parameter Non Spesifik Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana) Pada Variasi Asal Daerah. Farmasains, Vol. 2 No. 5 Hal. 202-207

Hezmela, R. 2006, Daya Antijamur Ekstrak Lengkuas Merah (Alpinia purpurata K. Schum) Dalam Sediaan Salep. Skripsi. Bogor: Fakultas Teknologi Pertanian Institut Pertanian Bogor.

Kartika, D. 2013, Aktivitas Antibakteri Fraksi Etanol - Air Dari Ekstrak Etanol Bawang putih (Allium sativum L.) Terhadap Bakteri Streptococcus mutans dan Pseudomonas aeroginosa serta bioautografi. Skripsi. Surakarta: Universitas Muhammadiyah Surakarta.

Karina, R. 2013, Pengaruh Ekstrak Bawang Putih (Allium sativum) terhadap pertumbuhan bakteri Streptococus mutans secara invitro. Skripsi. Jakarta: Fakultas Kedokteran dan Ilmu – Ilmu Kesehatan Universitas Islam Negeri Syarif Hidayatullah.

Kemenkes RI. 2011, Profil Kesehatan Indonesia 2010. Jakarta: Kementrian Kesehatan Republik Indonesia, pp: 40

Kshirsagar, N.A. 2000, Drug Delivery Systems. Indian Journal of Pharmacology, No. 32, Hal. S54-S61

Kute, S. B., & Saudagar, R. B. 2013, Emulsified Gel A Novel Approach for Delivery of Hydrophobic Drugs: An Overview. Journal of Advanced Pharmacy Education & Research, Vol. 3 No. 4 Hal. 368-376

Londhe, V.P., Gavasane, A.T., Nipate, S.S., Bandawane, D.D., & Chaudhari, P.D. 2011, Role of garlic (Allium sativum) in various disease : an overview. Journal Of Pharmaceutical Research And Opinion, Vol. 1 No.4 Hal. 129-134

Magdy, I.M. 2004, Optimation of Chlorphenesin Emulgel Formulation. The American Association of Pharmaceutical Scientists, Vol. 6 No. 3 Hal. 1-7

Majewski, M. 2014, Allium sativum: Facts and Myths Regarding Human Health. Journal of the National Institute of Public Health, Vol. 65 No. 1 Hal. 1-8

Martin, A., Swarbrick, J., & Cammarata, A., 1993, Farmasi Fisik: Dasar-dasar Kimia Fisik dalam Ilmu Farmasi. UI-PRESS, Jakarta.

Maulana, Akbar. 2016, Analisis Parameter Mutu Dan Kadar Flavonoid Pada Produk Teh Hitam Celup. Skripsi. Bandung: Universitas Pasundan,

Mikaili, P., Maadirad, S., Moloudizargari, M., Aghajanshakeri, S., & Shadi S. 2013, Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds. Iranian Journal of Basic Medical Sciences, Vol. 16 No. 10 Hal. 1031-1048

Mirhansyah, A., Vebry, A., & Arsyik, I. 2015, Formulasi Dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi. Journal of Tropical Pharmacy and Chemistry, Vol. 3 No. 2 Hal. 103

Naibaho, O.H., Yamlean, P.V.Y., & Wiyono, W. 2013, Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci Yang Dibuat Infeksi Staphylococcus aureus. Jurnal Ilmiah Farmasi, Vol. 2 No. 2 Hal. 27-34

Oktavia, M. 2008, Optimasi Komposisi Tween 80 dan Span 80 Sebagai Emulsifying Agent Dalam Formulasi Emulgel Anti - Aging Ekstrak Teh Hijau (Camellia sinensis (L) O.K) : Aplikasi Desain Faktorial. Skripsi. Yogyakarta: Universitas Sanata Dharma.

Panwar, A.S., Upadhyay, N., Bairagi, M., Gujar, S., Darwhekar, G.N., & Jain, D.K. 2011, Emulgel : A review. Asian Journal of Pharmacy and Life Science, Vol. 1 No. 3 Hal. 333-343

Pracaya. 2008, Pengendalian Hama & Penyakit Tanaman secara Organik. Yogyakarta: Penerbit Kanisius

Pratiwi, M. 2015, Uji Efek Antifertilitas Serbuk Umbi Lapis Bawang Putih (Allium sativum L.) Pada Tikus Jantan (Rattus novergicus) Galur Sprague dawley secara In Vivo dan In Vitro. Skripsi. Fakultas Kedokteran Dan Ilmu Kesehatan Program Studi Farmasi. UIN Syarif Hidayatullah Jakarta. Jakarta

Rao, Y., & Xiang, B. 2009, Determination of Total Ash and Acid-insoluble Ash of Chinese Herbal Medicine Prunellae spica by Near Infrared Spectroscopy. Yakugaku Zasshi, Vol. 129 No. 7 Hal 881-886

Rowe, R.C., Sheskey, P.J., & Quinn, M.E. 2009, Handbook Of Pharmaceutical Excipients. USA: Royal Pharmaceutical Society of Great Britain

Samadi, Budi. 2000, Usaha Tani Bawang Putih. Yogyakarta: Percetakan Kanisius

Santi, D.K., 2013, Aktivitas Antibakteri Fraksi Etanol-Air Dari Ekstrak Etanol Bawang Putih (Allium sativum L.) Terhadap Bakteri Streptococcus mutans dan Pseudomonas aeroginosa Serta Bioautografi. Skripsi. Surakarta: Fakultas Farmasi Universitas Muhammadiyah Surakarta.

Singla, V., Saini, S., Joshi, B., & Rana, A.C. 2012, Emulgel: A New Plathform for Topical Drug Delivery. International Journal of Pharma And Bio Sciences, Vol. 3 No. 1 Hal. 485-498

Sulistyorini, A. 2015, Potensi Antioksidan dan Antijamur Ekstrak Umbi Bawang Putih (Allium sativum Linn.) Dalam Beberapa Pelarut Organik. Skripsi. Malang: Universitas Islam Negeri Maulana Malik Ibrahim.

Syamsiah & Tajudin. 2003, Khasiat dan Manfaat Bawang Putih Raja Antibiotik Alami. Jakarta: Agromedia Pustaka

Trubus Info Kit. 2010, Herbal Indonesia Berkhasiat - Bukti Ilmiah & Cara Racik. Bogor: Trubus Swadaya

Ulaen, S.P.J., Banne, Y., Suatan, R.A. 2012, Pembuatan Salep Anti Jerawat Dari Ekstrak Rimpang Temulawak (Curcuma Xanthorriza Roxb.) Jurnal Ilmiah Farmasi. Vol. 3 No. 2 Hal. 45 - 49

Utami, Aras. 2006, Uji Banding Efektivitas Perasan Umbi Bawang Putih (Allium sativum Linn.) 25% Dengan Ketokonazol 2% Secara In Vitro Terhadap Pertumbuhan Candida Albicans Pada Kandidiasis Vaginalis. Skripsi. Semarang: Universitas Diponegoro.

Voight, R. (ed). 1994, Buku Pelajaran Teknologi Farmasi. 5th ed, Yogyakarta: Gadjah Mada University Press

Wade, A., & Waller, P.J. 2011, Handbook of Pharmaceutical Excipient. 2nd ed. London: The Pharmaceutical Press, pp: 201-220

World Health Organization. 1998, Quality Control Methods for Medicinal Plant Materials. 1st ed. Geneva: World Health Organization

Wu, Y., Iglauer, S., Shuler, P., Tang, Y., & Goddard III, W.A. 2016, Alkyl Polyglycoside-Sorbitan Ester Formulations for Improved Oil Recovery. Tenside Surfactants Detergents Journal, Vol. 47 No. 5 Hal. 280-287

Yenti, R., Ria, A., & Siti, Q. 2014, Formulasi Emulgel Ekstrak Etanol Daun Dewa (Gynura Pseudochina (L.) Dc) Untuk Pengobatan Nyeri Sendi Terhadap Tikus Putih Jantan. Skripsi. Padang: Prosiding Seminar Nasional dan Workshop “Perkembangan Terkini Sains Farmasi dan Klinik IV”. Padang.

Yudistira, A.A.A. 2017, Pengembangan Sediaan Nanoemulgel Piroksikam Menggunakan Minyak Vitamin E Asetat Dengan Surfaktan Labrasol Dan Kosurfaktan Plurol Oleique. Skripsi. Yogyakarta: Fakultas Farmasi Universitas Ahmad Dahlan.




DOI: https://doi.org/10.25077/jsfk.6.1.7-15.2019

Article Metrics

Abstract view : 905 times
PDF view/download : 2253 times



Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) | p-ISSN: 2407-7062 | e-ISSN: 2442-5435

Diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan Ikatan Apoteker Indonesia - Daerah Sumatera Barat 

       

 JSFK is licensed under Creative Commons Attribution-ShareAlike 4.0 International License.