Pembentukan Sistem Dispersi Padat Amorf Azitromisin Dihidrat dengan Hikroksipropil Metilselulosa (HPMC)

Erizal Zaini, Netty Novitasari, Maria Dona Octavia

Abstrak


Tujuan penelitian ini untuk mengembangkan sistem dispersi padat azitromisin dihidrat dengan pembawa hidroksipropil metilselulosa E5 LV agar laju disolusi azitromisin dihidrat meningkat. Dispersi padat amorf dibuat dengan metode pelarutan pada perbandingan obat : polimer 1:1; 1:2 and 2:1. Sifat padatan dispersi padat amorf dievaluasi dengan analisa difraksi sinar-X, mikroskopik SEM dan spekroskopi FT-IR. Lebih lanjut, profil laju disolusi dilakukan dengan alat uji disolusi tipe II USP. Menurut analisa difraksi sinar-X, azitromisin dihidrat mengalami transformasi sebagian dari fase kristalin ke fase amorf, yang diindikasikan dengan penururan secara signifikan puncak-puncak difraksi pada difraktogram. Analisis spektroskopi FT-IR membuktikan tidak terjadi interaksi secara kimiawi antara obat dan pembawa. Laju disolusi azitromisin dihidrat dari sistem dispersi padat amorf lebih tinggi dibandingkan azitromisin dihidrat murni dan campuran fisika. Laju disolusi azitromisin dihidrat meningkat dengan peningkatan rasio obat : polimer. 


Kata Kunci


azitromisin dihidrat; hidroksipropil metilselulosa; dispersi padat amorf; laju disolusi

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Referensi


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DOI: https://doi.org/10.25077/jsfk.3.2.165-171.2017

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